The “Histones and Chromatin” Review series published in EMBO Reports and The EMBO Journal includes six reviews centered around the histone code hypothesis. The reviews focus on histone variants and chaperones, histone modification writers, readers and erasers, and their role in nuclear organization, chromatin regulation, transcription and DNA repair. Technical advances for the study of chromatin-associated proteins are also covered. The review series provides a synthesis of the current state of the field and discusses open questions in a constructive manner. It aims to provide an overview by leaders in the field for the general reader and to share with those in the field the latest updates, concepts, and projections. We hope that you will enjoy reading it.
|Wrapping up histone regulation
The review series Histones and Chromatin in EMBO Reports explores state of the art molecular and mechanistic understanding of the regulation of chromatin at the histone level.
|Histones and histone modifications in perinuclear chromatin anchoring: from yeast to man
Jennifer C Harr, Adriana Gonzalez‐Sandoval, Susan M Gasser
The location of a gene in the nucleus correlates with its expression, but it is unclear whether there is a causal link. This review discusses how histone modifications and nuclear membrane proteins control the location and expression of genes across several species.
|Touch, act and go: landing and operating on nucleosomes
THE EMBO JOURNAL
Valentina Speranzini, Simona Pilotto, Titia K Sixma, Andrea Mattevi
This review summarizes the emerging structural understanding of nucleosome recognition by multiprotein readers, writers and erasers of chromatin marks, which are key for integrating information from both DNA and histone modifications.
|The H1 linker histones: multifunctional proteins beyond the nucleosomal core particle
Sonja P Hergeth, Robert Schneider
H1 linker histones are key structural chromatin components. This review discusses functions of the multiple H1 subtypes and their modifications beyond their structural role.
|The right place at the right time: chaperoning core histone variants
Francesca Mattiroli, Sheena D'Arcy, Karolin Luger
This review assesses the determinants of the specificity in histone variant‐histone chaperone interactions at the molecular and atomic level, and discusses biological roles of histone variants and chaperones.
|The interplay of histone modifications – writers that read
Tianyi Zhang, Sarah Cooper, Neil Brockdorff
Post‐translational histone modifications correlate with gene expression states. This review discusses how these modifications are formed, reinforced and maintained, and how their crosstalk might define gene expression states.
|Histone demethylases in chromatin biology and beyond
Emilia Dimitrova, Anne H Turberfield, Robert J Klose
Histone demethylases regulate chromatin biology and shape the epigenome. This review focuses on the mechanisms underlying histone demethylase function in a variety of cellular processes, including enzymatic activity‐independent roles and non‐histone substrates.
|Chromatin remodeling and bivalent histone modifications in embryonic stem cells
Arigela Harikumar, Eran Meshorer
This review discusses the emerging link between bivalent histone modifications and ATP‐dependent chromatin remodeling in pluripotent ESCs.