Table 1. Some of the viruses and immune evasion strategies discussed in this report
VirusFamily (genome)ProteinFunction/mechanism
Vaccinia virus (VV)Poxvirus (DNA)Interleukin 18 (IL‐18) binding protein (IL‐18BP)Secreted protein that binds IL‐18 and neutralizes its activity
Molluscum contagiosum virus (MCV)Poxvirus (DNA)IL‐18BPSecreted protein that binds IL‐18 and neutralizes its activity
Ectromelia virus (EV)Poxvirus (DNA)CD30Secreted protein that binds CD30 ligand
Fowlpox virus (FPV)Poxvirus (DNA)Interferon‐γ (IFN‐γ) receptorSecreted protein that binds IFN‐γ, unrelated to host receptor
Yaba‐like disease virus (YLDV)Poxvirus (DNA)Viral chemokine receptors (vCKRs)Membrane protein that binds chemokines
Human cytomegalovirus (HCMV)Herpesvirus (DNA)US28vCKR
US27, UL33vCKR homologues
US2, US11Degrade MHC class I molecules
US3, US10Interference with MHC class II presentation
Upregulation of CD95L and TRAIL and induction of apoptosis in T cells
Murine cytomegalovirus (MCMV)Herpesvirus (DNA)Viral chemokine (vCK)Chemoattractant properties
M04, M06Downregulation of MHC class I
M152Interferes with MHC class I presentation and NK cell activation
Kaposi's sarcoma‐associated herpesvirus (KSHV)Herpesvirus (DNA)vCKR ORF74Membrane protein that binds chemokines, consitutively activated, implicated in the development of Kaposi's sarcoma lesions
Murine γ‐herpesvirus 68 (MHV‐68)Herpesvirus (DNA)Viral chemokine binding protein (vCKBP) M3Secreted, binds and neutralizes chemokines
α‐herpesvirusesHerpesvirus (DNA)vCKBPSecreted, binds and neutralizes chemokines