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- Scientific ReportThe MYST family histone acetyltransferase complex regulates stress resistance and longevity through transcriptional control of DAF‐16/FOXO transcription factors
- 1Department of Cell and Developmental Biology, Graduate School of Biostudies, Kyoto University, Sakyo‐ku, Kyoto, Japan
- ↵*Corresponding author. Tel: +81 75 753 4230; E‐mail: nishida{at}lif.kyoto-u.ac.jp
FOXO transcription factors regulate stress resistance and longevity in diverse organisms. Here, the MYST family HAT complex is shown to increase FOXO transcription and thus promote longevity and stress resistance in C. elegans and human cells.
Synopsis
FOXO transcription factors regulate stress resistance and longevity in diverse organisms. Here, the MYST family HAT complex is shown to increase FOXO transcription and thus promote longevity and stress resistance in C. elegans and human cells.
The MYS‐1/TRR‐1 HAT complex regulates oxidative stress resistance and longevity by up‐regulating the expression of daf‐16 genes in C. elegans.
The Tip60/TRRAP HAT complex regulates cellular defense against oxidative stress by up‐regulating the expression of foxo1 gene in human cells.
The Tip60/TRRAP HAT is an evolutionarily conserved epigenetic regulator of FOXO transcription factors.
- Received January 6, 2017.
- Revision received July 12, 2017.
- Accepted July 13, 2017.
- © 2017 The Authors
- ArticleChromosome topology guides the Drosophila Dosage Compensation Complex for target gene activation
- Tamás Schauer1,
- Yad Ghavi‐Helm2,
- Tom Sexton3,
- Christian Albig1,
- Catherine Regnard1,
- Giacomo Cavalli4,5,
- Eileen EM Furlong2 and
- Peter B Becker (pbecker{at}bmc.med.lmu.de)*,1
- 1Molecular Biology Division, Biomedical Center and Center for Integrated Protein Science Ludwig‐Maximilians‐University, Munich, Germany
- 2European Molecular Biology Laboratory, Genome Biology Unit, Heidelberg, Germany
- 3Institute of Genetics and Molecular and Cellular Biology, Illkirch, France
- 4Institute of Human Genetics, CNRS, Montpellier, France
- 5University of Montpellier, Montpellier, France
- ↵*Corresponding author. Tel: +49 89 2180 75427; Fax: +49 89 2180 75425; E‐mail: pbecker{at}bmc.med.lmu.de
X chromosome loci with binding sites for the Drosophila MSL dosage compensation complex are engaged in long‐range interactions within the active compartment. The constitutive chromosome folding likely facilitates vital gene activation in male flies.
Synopsis
X chromosome loci with binding sites for the Drosophila MSL dosage compensation complex are engaged in long‐range interactions within the active compartment. The constitutive chromosome folding likely facilitates vital gene activation in male flies.
Dosage compensation profits from the compartment organization of the X chromosome.
Long‐range contacts between loci in the active compartment facilitate interactions between DCC binding sites.
The activation of genes correlates with their 3D proximity to DCC binding sites.
- Received March 27, 2017.
- Revision received June 30, 2017.
- Accepted July 4, 2017.
- © 2017 The Authors
- ArticleCircHIPK3 sponges miR‐558 to suppress heparanase expression in bladder cancer cells
- Yawei Li1,†,
- Fuxin Zheng1,†,
- Xingyuan Xiao1,
- Fei Xie1,
- Dan Tao2,
- Chao Huang1,
- Dong Liu1,
- Miao Wang1,
- Liang Wang1,
- Fuqing Zeng (zengfuqingpro{at}163.com)*,1 and
- Guosong Jiang (jiangguosongdoc{at}hotmail.com)*,1
- 1Department of Urology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China
- 2Department of Oncology, The Fifth Hospital of Wuhan, Wuhan, China
- ↵*
Corresponding author. Tel: +86 27 8535 1624; Fax: +86 27 8365 1606; E‐mail: zengfuqingpro{at}163.com
Corresponding author. Tel: +86 27 8535 1624; Fax: +86 27 8365 1606; E‐mail: jiangguosongdoc{at}hotmail.com
↵† These authors contributed equally to this work
Circular RNAs are suggested to exert crucial functions in regulating gene expression. Here, deregulated circRNAs in human bladder cancer tissues are identified, and circHIPK3 is shown to act as a tumour suppressive microRNA sponge.
Synopsis
Circular RNAs are suggested to exert crucial functions in regulating gene expression. Here, deregulated circRNAs in human bladder cancer tissues are identified, and circHIPK3 is shown to act as a tumour suppressive microRNA sponge.
circHIPK3 is down‐regulated in human bladder cancer tissues and cell lines.
circHIPK3 efficiently sponges miR‐558 in bladder cancer cells.
circHIPK3 inhibits cancer aggressiveness and metastasis by targeting the miR‐558/heparanase axis.
- Received October 28, 2016.
- Revision received June 25, 2017.
- Accepted June 30, 2017.
- © 2017 The Authors
- Science & SocietyThe problem with pseudosciencePseudoscience is not the antithesis of professional science but thrives in science's shadow
Pseudoscience is not the antithesis of professional science but thrives in science's shadow
- Michael D Gordin (mgordin{at}princeton.edu)1
Pseudoscience has been the bane of science since the latter became a professional activity. Rather than dismissing it as wrong, the more efficient way of dealing with pseudoscience's false claims is to stress the nature of science itself with all its problems and pitfalls.
- © 2017 The Author
- Science & SocietyThe reproducibility “crisis”Reaction to replication crisis should not stifle innovation
Reaction to replication crisis should not stifle innovation
- Philip Hunter, Freelance journalist (ph{at}philiphunter.com)1
The purported reproducibility crisis has triggered both studies to analyze the problem and proposals to address it. However, it is important to not stifle exploratory, cutting‐edge research.
- © 2017 The Author
- CorrespondenceUnintended consequences of 21st century technology for agricultural pest management
- Stephen L Young (sly27{at}cornell.edu)1
Comment on “Agricultural pest control with CRISPR‐based gene drive: time for public debate” by Courtier‐Orgogozo et al.
- © 2017 The Author
- CorrespondenceCRISPR‐based gene drive in agriculture will face technical and governance challenges
