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Review

Mitochondria and the dynamic control of stem cell homeostasis

Pawel Lisowski, Preethi Kannan, Barbara Mlody, View ORCID ProfileAlessandro Prigione
DOI 10.15252/embr.201745432 | Published online 16.04.2018
EMBO reports (2018) e45432
Pawel Lisowski
Max Delbrueck Center for Molecular Medicine (MDC), Berlin, GermanyInstitute of Genetics and Animal Breeding, Polish Academy of Sciences, Magdalenka, PolandCentre for Preclinical Research and Technology (CePT), Warsaw Medical University, Warsaw, Poland
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Preethi Kannan
Max Delbrueck Center for Molecular Medicine (MDC), Berlin, Germany
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Barbara Mlody
Max Delbrueck Center for Molecular Medicine (MDC), Berlin, Germany
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Alessandro Prigione
Max Delbrueck Center for Molecular Medicine (MDC), Berlin, Germany
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Author Affiliations

  1. Pawel Lisowski1,2,3,
  2. Preethi Kannan1,
  3. Barbara Mlody1 and
  4. Alessandro Prigione (alessandro.prigione{at}mdc-berlin.de)*,1
  1. 1Max Delbrueck Center for Molecular Medicine (MDC), Berlin, Germany
  2. 2Institute of Genetics and Animal Breeding, Polish Academy of Sciences, Magdalenka, Poland
  3. 3Centre for Preclinical Research and Technology (CePT), Warsaw Medical University, Warsaw, Poland
  1. ↵*Corresponding author. Tel: +49 30 9406 2871; Fax: +49 30 9406 3696; E‐mail: alessandro.prigione{at}mdc-berlin.de
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Abstract

The maintenance of cellular identity requires continuous adaptation to environmental changes. This process is particularly critical for stem cells, which need to preserve their differentiation potential over time. Among the mechanisms responsible for regulating cellular homeostatic responses, mitochondria are emerging as key players. Given their dynamic and multifaceted role in energy metabolism, redox, and calcium balance, as well as cell death, mitochondria appear at the interface between environmental cues and the control of epigenetic identity. In this review, we describe how mitochondria have been implicated in the processes of acquisition and loss of stemness, with a specific focus on pluripotency. Dissecting the biological functions of mitochondria in stem cell homeostasis and differentiation will provide essential knowledge to understand the dynamics of cell fate modulation, and to establish improved stem cell‐based medical applications.

  • differentiation
  • metabolism
  • mitochondria
  • pluripotency
  • PSCs

EMBO Reports (2018) e45432

  • Received November 3, 2017.
  • Revision received December 22, 2017.
  • Accepted March 21, 2018.
  • © 2018 The Authors
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In this Issue
Volume 19, Issue 4
01 April 2018 | pp -
EMBO reports: 19 (4)
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Article

  • Article
    • Abstract
    • Introduction
    • Mitochondrial metabolism and dynamics in stem cell homeostasis
    • Mitochondrial control of redox and calcium balance in stem cell homeostasis
    • Mitochondrial metabolism–epigenetics crosstalk in stem cell homeostasis
    • Concluding remarks
    • Conflict of interest
    • Acknowledgements
    • Footnotes
    • References
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