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News & Views

Parkin‐independent mitophagy—FKBP8 takes the stage

Grace GY Lim, Kah‐Leong Lim
DOI 10.15252/embr.201744313 | Published online 17.05.2017
EMBO reports (2017) e201744313
Grace GY Lim
Neurodegeneration Research Laboratory, National Neuroscience Institute, Singapore City, Singapore
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Kah‐Leong Lim
Neurodegeneration Research Laboratory, National Neuroscience Institute, Singapore City, SingaporeDepartment of Physiology, National University of Singapore, Singapore City, SingaporeDuke‐NUS Medical School, Singapore City, Singapore
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Author Affiliations

  1. Grace GY Lim1 and
  2. Kah‐Leong Lim (Kah_Leong_Lim{at}nni.com.sg)1,2,3
  1. 1Neurodegeneration Research Laboratory, National Neuroscience Institute, Singapore City, Singapore
  2. 2Department of Physiology, National University of Singapore, Singapore City, Singapore
  3. 3Duke‐NUS Medical School, Singapore City, Singapore
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    Figure 1. FKBP8 recruits LC3A to mediate mitophagy

    FKBP8 is normally localized to the outer membrane of the mitochondria. In response to mitochondrial depolarization, FKBP8 preferentially recruits the lipidated form of LC3A to initiate mitophagy. During the process, FKBP8 escapes to the endoplasmic reticulum to avoid being degraded, which is apparently important to prevent apoptosis from occurring during mitophagy.

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Volume 20, Issue 2
01 February 2019
EMBO reports: 20 (2)
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