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Of mice and CRISPR

The post‐CRISPR future of the mouse as a model system for the human condition
Edison T Liu, Ewelina Bolcun‐Filas, David S Grass, Cathleen Lutz, Steve Murray, Lenny Shultz, Nadia Rosenthal
DOI 10.15252/embr.201643717 | Published online 24.01.2017
EMBO reports (2017) e201643717
Edison T Liu
The Jackson Laboratory, Bar Harbor, ME, USA
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Ewelina Bolcun‐Filas
The Jackson Laboratory, Bar Harbor, ME, USA
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David S Grass
The Jackson Laboratory, Bar Harbor, ME, USA
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Cathleen Lutz
The Jackson Laboratory, Bar Harbor, ME, USA
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Steve Murray
The Jackson Laboratory, Bar Harbor, ME, USA
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Lenny Shultz
The Jackson Laboratory, Bar Harbor, ME, USA
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Nadia Rosenthal
The Jackson Laboratory, Bar Harbor, ME, USA
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Author Affiliations

  1. Edison T Liu (edison.liu{at}jax.org)1,
  2. Ewelina Bolcun‐Filas1,
  3. David S Grass1,
  4. Cathleen Lutz1,
  5. Steve Murray1,
  6. Lenny Shultz1 and
  7. Nadia Rosenthal1
  1. 1The Jackson Laboratory, Bar Harbor, ME, USA
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Article Information

DOI 
https://doi.org/10.15252/embr.201643717
PubMed 
28119373
Print ISSN 
1469-221X
Online ISSN 
1469-3178
History 
  • Published online January 24, 2017.

Author Information

  1. Edison T Liu (edison.liu@jax.org)1,
  2. Ewelina Bolcun‐Filas1,
  3. David S Grass1,
  4. Cathleen Lutz1,
  5. Steve Murray1,
  6. Lenny Shultz1 and
  7. Nadia Rosenthal1
  1. 1The Jackson Laboratory, Bar Harbor, ME, USA
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In this Issue
Volume 19, Issue 4
01 April 2018 | pp -
EMBO reports: 19 (4)
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Article

  • Article
    • The mouse as experimental model
    • The impact of CRISPR/Cas
    • Modeling the genetic diversity of a disease
    • Assessing combinatorial gene effects
    • The “sapienization” of the mouse
    • A comprehensive understanding of genetic backgrounds
    • Challenges from other model systems
    • What does it mean for mouse facilities?
    • Conflict of interest
    • References
  • Figures & Data
  • Transparent Process

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