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The Hippo signaling pathway in stem cell biology and cancer

Jung‐Soon Mo, Hyun Woo Park, Kun‐Liang Guan

Author Affiliations

  1. Jung‐Soon Mo1,
  2. Hyun Woo Park1 and
  3. Kun‐Liang Guan*,1
  1. 1Department of Pharmacology and Moores Cancer Center, University of California, San Diego La Jolla, CA, USA
  1. *Corresponding author. Tel: +1 858 822 7945; E‐mail: kuguan{at}ucsd.edu

Abstract

The Hippo signaling pathway, consisting of a highly conserved kinase cascade (MST and Lats) and downstream transcription coactivators (YAP and TAZ), plays a key role in tissue homeostasis and organ size control by regulating tissue‐specific stem cells. Moreover, this pathway plays a prominent role in tissue repair and regeneration. Dysregulation of the Hippo pathway is associated with cancer development. Recent studies have revealed a complex network of upstream inputs, including cell density, mechanical sensation, and G‐protein‐coupled receptor (GPCR) signaling, that modulate Hippo pathway activity. This review focuses on the role of the Hippo pathway in stem cell biology and its potential implications in tissue homeostasis and cancer.

  • Received February 17, 2014.
  • Revision received April 16, 2014.
  • Accepted April 16, 2014.

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