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Ubiquitin in the immune system

Julia Zinngrebe, Antonella Montinaro, Nieves Peltzer, Henning Walczak

Author Affiliations

  1. Julia Zinngrebe1,,
  2. Antonella Montinaro1,,
  3. Nieves Peltzer1, and
  4. Henning Walczak*,1
  1. 1Centre for Cell Death, Cancer, and Inflammation (CCCI) UCL Cancer Institute, University College London, London, UK
  1. *Corresponding author. Tel: +44 207 679 46471; Fax: +44 207 679 6925; E‐mail: h.walczak{at}ucl.ac.uk
  1. These authors contributed equally to the review.

View Abstract

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Abstract

Ubiquitination is a post‐translational modification process that has been implicated in the regulation of innate and adaptive immune responses. There is increasing evidence that both ubiquitination and its reversal, deubiquitination, play crucial roles not only during the development of the immune system but also in the orchestration of an immune response by ensuring the proper functioning of the different cell types that constitute the immune system. Here, we provide an overview of the latest discoveries in this field and discuss how they impact our understanding of the ubiquitin system in host defence mechanisms as well as self‐tolerance.

Footnotes

  • See the Glossary for abbreviations used in this article.

  • The authors declare that they have no conflict of interest.

  • Received September 24, 2013.
  • Revision received November 11, 2013.
  • Accepted November 13, 2013.
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