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The IκB kinase complex in NF‐κB regulation and beyond

Michael Hinz, Claus Scheidereit

Author Affiliations

  1. Michael Hinz1 and
  2. Claus Scheidereit*,1
  1. 1Max Delbrück Center for Molecular Medicine, Berlin, Germany
  1. *Corresponding author. Tel: +49 30 9604 3816; Fax: +49 30 9604 3866; E‐mail: scheidereit{at}mdc-berlin.de

Abstract

The IκB kinase (IKK) complex is the signal integration hub for NF‐κB activation. Composed of two serine‐threonine kinases (IKKα and IKKβ) and the regulatory subunit NEMO (also known as IKKγ), the IKK complex integrates signals from all NF‐κB activating stimuli to catalyze the phosphorylation of various IκB and NF‐κB proteins, as well as of other substrates. Since the discovery of the IKK complex components about 15 years ago, tremendous progress has been made in the understanding of the IKK architecture and its integration into signaling networks. In addition to the control of NF‐κB, IKK subunits mediate the crosstalk with other pathways, thereby extending the complexity of their biological function. This review summarizes recent advances in IKK biology and focuses on emerging aspects of IKK structure, regulation and function.

Footnotes

  • See the Glossary for abbreviations used in this article.

  • The authors declare that they have no conflict of interest.

  • Received September 11, 2013.
  • Revision received October 31, 2013.
  • Accepted November 6, 2013.

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