We are pleased to introduce the new members of the EMBO reports Advisory Editorial Board. Members of the Board provide scientific advice to the editors for which we are very grateful. A full list of the Advisory Editorial Board is also available.
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Professor of Molecular Medicine at the University of Gothenburg, Sweden
Fredrik is director of the Wallenberg Laboratory for Cardiovascular and Metabolic Research. During his postdoctoral training he developed the concept that the gut microbiota may function as an environmental factor that contributes to adiposity. His group currently employs a translational approach of examining the metagenome of well-phenotyped patients in combination with advanced gnotobiotic mouse models to understand host-microbial cross-talk and its contribution to metabolic diseases such as diabetes and cardiovascular disease. He currently also holds a professorship at Copenhagen University, Denmark, and is co-founder of MetaboGen AB located in Gothenburg, Sweden.
|Vytas A Bankaitis
Professor, Department of Cell & Developmental Biology at the University of North Carolina School of Medicine, USA
Vytas's laboratory uses a multidisciplinary approach to investigate how lipids and lipid metabolism interface with membrane trafficking and cell growth control with a particular focus on the roles of phosphatidylinositol transfer proteins and oxysterol binding proteins in these processes.
Emeritus President of the Donald Danforth Plant Science Center in St. Louis, USA
Roger is former Director of the National Institute of Food and Agriculture (USA). At the Danforth Center, his group focuses on the cellular and molecular mechanisms of virus infection in plants and develops strategies to control virus diseases in transgenic plants, and to control gene expression in plants. In collaboration with Monsanto scientists, he developed the first genetically modified food crop, a tomato modified for resistance to virus disease.
Professor, Department of Pathology, School of Medicine, University of Colorado, USA
David's interests are in how mRNA synthesis and processing are coordinated with one another to achieve accurate and efficient production of the mature mRNP. His lab has investigated the control of transcriptional elongation and the integration of transcription with mRNA processing using molecular genetic approaches in yeast and mammalian cells. Much of his work explores the "mRNA factory" model, which proposes that transcription and mRNA maturation are coupled through the binding of processing factors to the C-terminal domain, a signature feature of RNA polymerase II, as it traverses the gene.
|Arthur L Caplan
William F and Virginia Connolly Mitty Professor and founding head of the Division of Bioethics at New York University Langone Medical Center, USA
Arthur has served on a number of national and international committees including as the Chair of the National Cancer Institute Biobanking Ethics Working Group; the Chair of the Advisory Committee to the United Nations on Human Cloning; the Chair of the Advisory Committee to the Department of Health and Human Services on Blood Safety and Availability; a member of the Presidential Advisory Committee on Gulf War Illnesses; the special advisory committee to the International Olympic Committee on genetics and gene therapy; the ethics committee of the American Society of Gene Therapy; and the special advisory panel to the National Institutes of Mental Health on human experimentation on vulnerable subjects. He recently served as the Co-Director of the Joint Council of Europe/United Nations Study on Trafficking in Organs and Body Parts. He is currently the ethics advisor to DOD/DARPA on synthetic biology.
Canada Research Chair in Health Law and Policy, Professor in the Faculty of Law and the School of Public Health and Research Director of the Health Law and Science Policy Group at the University of Alberta, Canada.
Over the past several years, Tim has been involved in a variety of interdisciplinary research endeavours that have allowed him to explore the ethical, legal and health policy issues associated with a range of topics, including stem cell research, genetics, patient safety, the prevention of chronic disease, obesity policy, the commercialization of research, complementary and alternative medicine and access to health care. He is and has been involved with a number of national and international policy and research ethics committees, including Canadian Biotechnology Advisory Committee, Genome Canada's Science Advisory Committee, and the Federal Panel on Research Ethics.
Professor and Roy J Carver Biomedical Research Chair in the Department of Internal Medicine, University of Iowa, USA
Beverly's work is focused on the development of molecular therapies for inherited disorders of the central nervous system. Her group has made pioneering contributions to the application of RNA interference-based platforms for in vivo studies and therapeutic use. Her lab has also advanced the use of viral-mediated gene delivery systems as therapeutic and research tools. She uses cellular, molecular and biochemical approaches in established and novel model systems to better understand the underpinnings of neurological disease.
|Catherine L Drennan
Professor of Chemistry and Biology at the Massachusetts Institute of Technology and Professor and Investigator with the Howard Hughes Medical Institute, USA
Cathy's research interests lie at the interface of chemistry and biology. Her laboratory seeks to understand how Nature harnesses and re-directs the reactivity of enzyme metallocenters in order to perform challenging reactions. By combining X-ray crystallography with other biophysical methods, her goal is to "visualize" molecular processes by obtaining snapshots of enzymes in action.
Senior Investigator, Samuel Lunenfeld Research Institute, Mount Sinai Hospital and Professor in the Department of Molecular Genetics at the University of Toronto, Canada
Daniel's interest is in understanding how cells maintain the integrity of their genome and his lab currently works on elucidating how cells organize the response to DNA double-strand breaks, with a particular focus on how histone ubiquitylation orchestrates the recruitment of DNA damage repair and signaling proteins at the site of the lesion. His lab is also interested in using the response to DNA damage as a tool to study reversible protein ubiquitylation.
|Zvulun (Zevi) Elazar
Harold Korda Professor at the Department of Biological Chemistry of the Weizmann Institute of Science in Rehovot, Israel
Zvulun studies different mechanistic aspects of autophagy in yeast and mammalian systems. He is particularly interested in the role of the Atg8s, unique ubiquitin-like proteins that are part of the core autophagic machinery. This family facilitates both autophagosome formation and selective cargo recruitment into these organelles. The current focus of his lab is on the identification of factors that regulate these processes and are defective in pathophysiological conditions such as neurodegeneration and cancer.
Professor and Head, Department of Genome Dynamics & Function at the Centro de Biologia Molecular Severo Ochoa, Madrid, Spain
Crisanto's group uses a multidisciplinary approach to decipher the mechanisms regulating cell proliferation and DNA replication during development, with a primary focus in the model plant Arabidopsis, and the crosstalk with epigenetics and gene expression. His laboratory has contributed to elucidating mechanisms controlling cell cycle progression, DNA replication and endoreplication, and chromatin dynamics. He is also interested in the identification of cellular factors transferring hormonal, developmental and environmental cues into the pathways regulating the entry and exit into the cell cycle and the acquisition of particular cell fates.
Professor and Director at the Department of Plant Molecular Biology, University of Lausanne, Switzerland.
The research in Christian's laboratory revolves around the molecular genetic control of plant development, with a focus on genes that modify quantitative aspects of plant growth and morphology. He is particularly interested in the hormonal control of root system architecture and secondary vascular growth, with an occasional evolutionary ecology twist. His lab uses two experimental organisms, the dicotyledon model Arabidopsis thaliana, and the monocotyledon model, Brachypodium distachyon.
|Daniel L Hartl
Higgins Professor of Biology, Department of Organismic and Evolutionary Biology at Harvard University, USA
Daniel's laboratory studies genetics, genomics and molecular evolution of model organisms and human pathogens. Current studies include epigenetic effects of the Drosophila Y chromosome on gene expression, the molecular evolution of drug resistance in malaria and bacteria, and the population genomics of malaria parasites.
Senior Group Leader, VIB Center for the Biology of Disease at VIB and KU Leuven School of Medicine, Belgium
Bassem's work is focused on understanding the mechanisms that underlie the development and differentiation of neuronal lineages. His group uses genetic, molecular and cell biological approaches to unravel the regulatory interactions and signaling pathways which determine neural precursor cells and lead to the differentiation of functional neuronal elements. Bassem is also interested in the processes that undermine normal development and differentiation and which, consequently, lead to neuronal pathologies.
Director and Professor of Molecular Pharmacology at the Leibniz Institute for Molecular Pharmacology and the Free University of Berlin, Germany
Volker works on the visualization and manipulation of the endocytic machinery and of endosomal membrane organization using a combination of biochemical, genetic, chemical, and optical imaging approaches with a particular focus on the nervous system.
Senior Principal Investigator, Shanghai Center for Plant Stress Biology, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, China
Yuehui is interested in plant molecular development and chromatin-regulatory mechanisms underlying the regulation of plant gene expression. A major thrust of his research is to explore the chromatin-based or epigenetic mechanisms for the control of developmental transition to flowering. In addition, his group is studying chromatin-mediated environmental and hormonal regulation of developmental gene expression in plants.
American Cancer Society Professor, Dept. of Biochemistry and Biophysics, University of California, San Francisco, USA
Cynthia's interest is in ageing and the genes and cells that control it. Her pioneering studies with C. elegans led to the realization that conserved hormone-signaling pathways and transcription factors can extend lifespan in many species, likely including humans. The long-lived mutants Kenyon and others have identified are resistant to many age-related diseases, raising the possibility of combating many diseases all at once by targeting aging itself.
Professor of Cell Biology and Max-Planck Fellow, Medical School of Philipps-Universität Marburg, Germany
Roland's lab is interested in the biogenesis and function of cellular iron-sulfur proteins. His group has identified and biochemically characterized many of the components of the mitochondrial and cytosolic biogenesis machineries that assemble iron-sulfur clusters and insert them into target apoproteins. Research in Roland's group also focuses on the molecular basis of diseases associated with genetic defects in iron-sulfur protein biogenesis, and on tightly associated processes such as cellular iron regulation and the maintenance of genome integrity.
Professor and ARC Federation Fellow in the School of Biomedical Sciences at Monash University, Australia
Trevor's lab works on protein transport across membranes, with current research projects including the discovery of new protein transport machines in bacteria, and understanding the assembly of protein transport machines in the outer membranes of bacteria and mitochondria. The evolution of these machines, from bacterial ancestors to mitochondria, is of special interest.
The Edna K Papazian Distinguished Service Professor of Evolution and Genetics at the University of Chicago, USA.
Manyuan's passion is the origin and evolution of new genes and related problems in evolution and genetics. Using experimental and computational techniques, Manyuan has shown that the origins of new genes are a general process in evolution in which functional novelties lead to the great diversity of life in nature. His interests also include the detection of recent evolution in the genetic control of development, brain and behavior in animals, and the genetic dissection of sexual dimorphism, in addition to the systems analysis of local and global pathways.
Professor and Director, Novo Nordisk Foundation Center for Protein Research, Faculty of Health and Medical Sciences, University of Copenhagen, Denmark
Jiri studies spatial and temporal dynamics of chromosomes during the mammalian cell division cycle and after DNA damage, with an emphasis on how these mechanisms are subverted in diseases associated with genome instability. His long-term interests also include high-content microscopy screens for genome caretakers and the development of real-time imaging techniques. Among the recent discoveries from Jiri's lab is the identification of a ubiquitin driven signaling pathway that barcodes chromatin near the DNA lesions to assemble repair and signaling proteins.
Professor and Head of the Department of Infectious Diseases at Kings College London, UK
Michael's laboratory utilises molecular genetic, cultured cell, biochemical, structural, bioinformatic and cohort-based methodologies to study the biological principles that underpin HIV replication and pathogenesis (AIDS). Current areas of interest include host-virus interactions, cell-encoded mechanisms of anti-viral resistance and virus particle assembly.
Professor and HHMI Investigator at Cold Spring Harbor Laboratory, USA
Research in Rob's laboratory focuses on epigenetic mechanisms that shape and regulate the genome, and their impact on development and inheritance. His work on transposable elements in plants and repetitive sequences in yeast has revealed a link between heterochromatin and RNA interference (named "Breakthrough of the Year"), for which he received the AAAS Newcomb Cleveland Award in 2003.
|Randall T Moon
Investigator at the Howard Hughes Medical Institute, Professor of Pharmacology at the University of Washington School of Medicine, and Founding Director of the Institute for Stem Cell and Regenerative Medicine, USA
Randall's academic research focuses on the functions and mechanisms of action of Wnt signal transduction pathways during embryonic development and in human disease. He is also a co-founder of Fate Therapeutics, located in San Diego, USA.
Professor of Systems Biology and Medicine at Harvard Medical School, USA
Vamsi's laboratory, based at Massachusetts General Hospital and the Broad Institute, focuses on basic mitochondrial biology and orphan mitochondrial disorders. His group has applied mass spectrometry and computation to characterize the mitochondrial proteome. In recent years, it has combined genetics, genomics, and physiology to discover numerous human disease genes, as well as the genes encoding the mitochondrial calcium uniporter.
|Sean J Morrison
Director, Children's Research Institute and Mary McDermott Cook Chair in Pediatric Genetics, University of Texas Southwestern Medical Center; Investigator, Howard Hughes Medical Institute, USA
Sean's laboratory studies the cellular and molecular mechanisms that regulate stem cell function in the nervous and hematopoietic systems and the role these mechanisms play in cancer. He has also been active in public policy issues surrounding stem cell research, has twice testified before Congress, and was a leader in the successful "Proposal 2" campaign to protect and regulate stem cell research in Michigan's state constitution.
Professor of Genetics at Harvard Medical School and Investigator, Howard Hughes Medical Institute, USA
Norbert has 30 years of experience in the fields of developmental genetics, signal transduction and genomics. By developing, improving, and applying a number of genetic techniques, his group identified many key components of the Receptor Tyrosine Kinases, JAK/STAT, Wnt, Hedgehog and Notch signaling pathways. Currently, his laboratory is applying large-scale RNAi and proteomic methods to obtain a global understanding to the structure of a number of signaling pathways and their cross-talks. In addition, he is studying the roles of signaling pathways in homeostasis and tissue regeneration in Drosophila muscles and gut stem cells, respectively.
Professor in Molecular Biology, Section of Histology and Embryology, Deptartment of Medical Biotechnologies, University of Padua, Italy
Stefano studies how cells sense their environment and uses this information to build and maintain tissues with specific form, size and function. He investigates the mechanisms by which growth factors and the cell's architectural, mechanical, and cytoskeletal cues regulate gene expression. He is also interested in how disruption of these homeostatic mechanisms leads to tumor formation, progression and metastasis, hoping to identify new routes for cancer treatment.
Group Leader at the Gurdon Institute in Cambridge, UK
Jonathon's laboratory focuses on the regulation of mitosis by protein phosphorylation and proteolysis. His work combines live cell microscopy with biochemistry to understand how the cyclin-dependent kinases drive cells to divide, and how chromosome segregation is regulated by the spindle assembly checkpoint and its target ubiquitin ligase (the APC/C).
|Joseph (Jody) Puglisi
Professor and Chair in the Department of Structural Biology at Stanford University, USA
Jody's research focuses on the role of structure and dynamics in biological processes involving RNA. His group uses a range of structural and biophyiscal methods including NMR spectroscopy and single-molecule approaches. His current focus is on the mechanism and regulation of translation
Associate Professor for Cell and Developmental Biology at the University of California at Berkeley, USA
Michael's lab at Berkeley discovered the K11-linked ubiquitin chain, the mechanism of linkage-specific chain formation, and recently, a ubiquitin-dependent mechanism that regulates vesicle size. Current work in his lab seeks to discover ubiquitination enzymes that control proliferation and differentiation, identify the pathways regulated by these enzymes during cell cycle control, dissect the biochemical mechanisms of ubiquitination, and isolate small molecule agonists and antagonists of ubiquitination.
Professor of Biology, Howard Hughes Medical Institute, USA
Michael is interested in RNA processing and the genes and mechanisms that underlie circadian rhythms. In the 1990s, work in his lab revealed that the period gene, per, and its encoded protein are important for a negative-feedback loop of gene expression. Current work in his lab seeks to understand in mechanistic detail how the Drosophila circadian timing occurs, how circadian gene expression regulation takes place, and the neural circuit(s) relevant to circadian timekeeping within the fruit fly brain and the functions of individual circadian neurons.
Professor of Medicine and Computer Science, Tel-Aviv University, Israel
Eytan's focus is computational systems biology with an emphasis on genome scale metabolic modeling (GSSM) of human, microbial and plant metabolism. His lab published the first large-scale computational description of healthy metabolism across different human tissues and is currently using GSSM to study liver and cancer metabolism and metabolic alterations accompanying aging and Alzheimer's.
Vice President of the Robert Koch Institute (RKI), Head of the Centre for Biological Threats and Special Pathogens at RKI, Berlin, Germany
Lars' department is charged with preparedness and response to high-threat biological agents that either occur naturally or are deliberately released. The centre covers a wide range of highly pathogenic bacteria, viruses and proteotoxins and serves as a federal reference institution. It provides diagnostics, assesses threats and risks to public health, advises in biosecurity issues and supports the management of biological incidents. Particular research interests of Lars and his colleagues at the centre are the host range of poxviruses, genome plasticity of the Bacillus cereus group, variability and functionality of selected biological toxins and rapid and generic diagnostics of pathogens (e.g. electron microscopy, next generation sequencing, spectrometry).
Associate Professor, Blavatnik School of Computer Science, Tel Aviv University, Tel Aviv, Israel
Roded's work is focused on network biology with an emphasis on inferring signaling-regulatory pathways that underlie processes of interest. The inference employs graph theoretic and integer programming methods to elucidate the topology of the pathway under investigation and learn a full logical model that describes its workings. His group applies this methodology to decipher disease mechanisms and drug response pathways and to further the functional annotation of protein networks.
Professor in the Department of Molecular Biology at Keio University School of Medicine, Japan
Haruhiko's research focuses on many aspects of RNA silencing including biogenesis of small silencing RNAs, transposon silencing, Argonaute proteins and their roles in transcriptional and post-transcriptional silencing.
|Nicholas H Steneck
Professor Emeritus of History and Director, MICHR Research Ethics Program at the University of Michigan, USA
Nick's work on research integrity began in 1984, when he chaired Michigan's pioneering Task Force on Integrity in Scholarship (1984). From 1991 to 1993, he chaired the Public Health Service Advisory Committee on Research Integrity. Nick helped establish the ORI/NIH Research on Research Integrity Program, co-chaired six ORI Research Integrity Conferences (2000, 2002, 2004, 2006, 2008, and 2009) and co-organized and co-chaired the first and second World Conferences on Research Integrity (Portugal 2007, Singapore, 2010). He was instrumental in the development of the Singapore Statement on Research Integrity and is currently the lead advisor to a new international online research integrity training program developed by the UK company, Epigeum.
Harvey M Meyerhoff Professor of Bioethics and Medicine, Berman Institute of Bioethics, Johns Hopkins University, USA
Jeremy is an internationally recognized leader in the field of biomedical ethics with particular expertise in the application of empirical methods and evidence-based standards for the evaluation and analysis of bioethical issues. His contributions to both medical ethics and policy include his work on the ethics of informed consent, umbilical cord blood banking, stem cell research, international HIV prevention research, and research oversight.
|Michael R Sussman
Professor, Department of Biochemistry & Director, University of Wisconsin Biotechnology Center, USA
Mike's research interests focus on using Arabidopsis thaliana to understand the role of plasma membrane proteins in signal transduction and solute transport. His laboratory was the first to report on unique protein kinases found only in plants and protists, and on the plasma membrane proton pump, which provides the driving force for the uptake of all nutrients. To help understand the in situ role played by these important proteins, Mike's laboratory pioneered the development of genome-wide reverse genetics techniques to isolate 'knockout' plants. His lab was the first to demonstrate that the plant homologue for a brain potassium channel is performing a nutritional role in higher plants, and has recently pioneered a new mass spectrometric approach for identifying key proteins involved in drought resistance. In addition to this biological focus, his laboratory develops and utilizes new genomic technologies, including the invention of a new way to make DNA chips on a maskless array synthesizer, which was commercialized by a company he founded, NimbleGen Systems, Inc., which was sold to Roche in 2006.
|Jesper Q Svejstrup
Senior Scientist, Cancer Research UK
Jesper's lab focuses on basic mechanisms that govern the interface between RNA polymerase II transcription and other DNA-related cellular processes, such as DNA repair, recombination and chromatin remodeling. Using biochemical fractionation and mass spectrometry, the Svejstrup lab has identified several important factors involved in different aspects of transcript elongation, and has contributed to outlining the biochemistry underlying their function. Jesper has traditionally used the yeast, Saccharomyces cerevisiae, as a model system, but is now increasingly working with mammalian cells and proteins.
Research Director (Professor) at the Institute of Molecular Biology and Biotechnology, in Heraklion, Crete, Greece
Nektarios's main interests are the molecular mechanisms of necrotic cell death in neurodegeneration and senescent decline, the molecular mechanisms of sensory transduction and integration by the nervous system, the interplay between cellular metabolism and ageing, and the development of novel genetic tools for C. elegans research.
|Dan S Tawfik
Nella and Leo Benoziyo Professor at the Department of Biological Chemistry of the Weizmann Institute of Science in Rehovot, Israel
Dan entered the field of protein evolution through his interest in enzyme engineering, when he realized that unraveling the mysteries of protein evolution is a charming intellectual endeavour as well as a powerful way of facilitating protein engineering. Research in the Tawfik laboratory integrates protein science, and chemical and evolutionary biology.
Director and Adjunct Professor of Laboratory Animal Centre at the University of Oulu, Finland
Hanna-Marja is a veterinarian specialized in laboratory animal medicine (DipECLAM) and has almost 30 years experience in laboratory animal science. Her research focuses on the refinement and reduction possibilities in animal experimentation–for example, improving environmental factors: sounds, bedding and enrichment–and refining techniques when handling animals. She is an active member of European laboratory animal science associations. She is a member of the Finnish National Animal Experiment Board, which grants licenses for animal experiments. In her laboratory, the ethical working and welfare of the animals is a key issue.
Principal Research Scientist, Division of Plant Industry, Commonwealth Scientific and Industrial Research Organisation (CSIRO), Australia
Ming-Bo joined CSIRO in 1994 and has been working on some of the mechanistic and applied aspects of RNA silencing in plants, including the development of the hairpin RNA gene silencing technology. His group currently focuses on the biological role of small RNAs and long noncoding RNAs in viral and fungal disease resistance in plants.
Laboratory of Chromosome Dynamics, Institute of Molecular and Cellular Biosciences, University of Tokyo, Japan
Yoshinori studies molecular mechanisms to determine chromosome orientation. He is particularly interested in reductional chromosome segregation, a fundamental mechanism that operates only in germ cells to reduce chromosome number by half and is governed mainly by cohesin complexes as well as meiosis-specific kinetochore molecules, shugoshin and Moa1.
Director, Division of Compliance Oversight, Office of Laboratory Animal Welfare (OLAW), NIH
At OLAW, Axel has also served as a Senior Assurance officer. Prior to joining OLAW, he was the director of the Veterinary Resources Program, NIH's intramural biomedical research support program. He also directed NIH's animal quarantine facility and served at the neurology institute. Axel's interest in unique research animals has involved him in work with armadillos, chimpanzees, and fruit bats, as well as the more common species. He has published on various topics including primate enrichment and interpretations of various provisions of the Public Health Service Policy on Humane Care and Use of Laboratory Animals.
Director of IMB and Academician, Academia Sinica, Taiwan
Meng-Chao's research is in the areas of chromosome structure and function, nucleolus function, genome instability and RNA interference. He was among the first to discover and define the global DNA rearrangement processes in Tetrahymena. He has been a key player in establishing ciliates as model organisms for molecular studies, and is credited for establishing the first DNA-mediated transformation of a protozoan.
Investigator, Institute of Biophysics, Chinese Academy of Sciences, China, and an HHMI International Early Career Scientist
Hong's lab focuses on the molecular mechanisms of the autophagy pathway, demonstrating that a variety of protein aggregates are selectively removed by autophagy during embryogenesis, and establishing C. elegans as a suitable model for genetic screens to study autophagy. His group has also identified multiple autophagy genes specific to multicellular organisms, has investigated the mechanism by which protein aggregates are selectively degraded by autophagy, and has studied the physiological functions of autophagy during C. elegans development.
Professor of Ecology and Evolutionary Biology at the University of Michigan, USA
Jianzhi has a wide array of research interests in molecular and genomic evolution, including the molecular basis of adaptation, evolution of duplicate genes, gene expression and expression noise, evolutionary genomics, and evolutionary systems biology. His research combines theoretical modeling, empirical data analysis, and experimental molecular biology.
|Raymond A Zilinskas
Director of the Chemical and Biological Weapons Nonproliferation Program, Monterey Institute of International Studies, USA
Raymond's research focuses on achieving effective biological arms control, assessing the proliferation potential of the former Soviet Union's biological warfare program, the implications of emerging biotechnologies for biological warfare and terrorism, and improving preparedness for and response to biological and chemical events by state and local public health agencies.