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Function and regulation of protein neddylation

Gwénaël Rabut, Matthias Peter

Author Affiliations

  1. Gwénaël Rabut*,1 and
  2. Matthias Peter*,1
  1. 1 Swiss Federal Institute of Technology Zürich (ETH), Institute of Biochemistry, 8093, Zürich, Switzerland
  1. *Tel: +41 44 633 4587; Fax: +41 44 632 1269; E‐mail: gwenael.rabut{at}bc.biol.ethz.ch or Tel: +41 44 633 6586; Fax: +41 44 632 1269; E‐mail: matthias.peter{at}bc.biol.ethz.ch
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Abstract

Neddylation is the post‐translational protein modification that is most closely related to ubiquitination. However, ubiquitination is known to regulate a myriad of processes in eukaryotic cells, whereas only a limited number of neddylation substrates have been described to date. Here, we review the principles of protein neddylation and highlight the mechanisms that ensure the specificity of neddylation over ubiquitination. As numerous neddylation substrates probably remain to be discovered, we propose some criteria that could be used as guidelines for the characterization of neddylated proteins.

  • Received June 9, 2008.
  • Accepted August 25, 2008.
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