01 December 2015; volume 16, issue 12
Cover: The unfolded protein response (UPR) is a stress signaling network that alleviates protein folding perturbations in the endoplasmic reticulum. The most conserved branch of the UPR relies on the splicing of XBP1 mRNA, which results in the synthesis of a potent transcription factor. A zipper‐like RNA conformational change ensures the fidelity of this non‐conventional splicing reaction to shut down ER stress. From Jirka Peschek, Diego Acosta‐Alvear, Aaron S. Mendez and Peter Walter: A conformational RNA zipper promotes intron ejection during non‐conventional XBP1 mRNA splicing. For details, see the Article on p 1688. © Cover image by Diego Acosta‐Alvear and Jirka Peschek. University of California San Francisco.