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Table of Contents

01 December 2013; volume 14, issue 12

  • Upfront
    • Editorial
    • Opinion
    • Correspondence
    • Hot off the Press
  • Science & Society
  • Review
  • Scientific Reports

Upfront

  • Editorial

    • You have access
      Science is the drug
      1. Howy Jacobs

      … in which Howy confesses to some eccentric proclivities.

      • Copyright © 2013 European Molecular Biology Organization
      Howy Jacobs
      Published online 01.12.2013
      • S&S: Health & Disease
      • S&S: Politics, Policy & Law
    • You have access
      Three sides of a coin
      1. Holger Breithaupt

      The ‘Drugs & Science’ series in EMBO reports will highlight the therapeutic, the risky and the societal aspects of drug use and abuse.

      • Copyright © 2013 European Molecular Biology Organization
      Holger Breithaupt
      Published online 01.12.2013
      • S&S: Health & Disease
      • S&S: Politics, Policy & Law
  • Opinion

    • You have access
      Thirteen follies and fallacies about alternative medicine
      1. Edzard Ernst1
      1. 1 University of Exeter, UK

      Thirteen common misunderstandings about alternative medicine and the consequences for health.

      • Copyright © 2013 European Molecular Biology Organization
      Edzard Ernst
      Published online 01.12.2013
      • S&S: Health & Disease
      • S&S: Politics, Policy & Law
  • Correspondence

    • You have access
      Comment on the Howy Jacobs' Editorial “Yes we can, but do we?”
      Abraham L Sonenshein
      Published online 01.12.2013
      • S&S: Politics, Policy & Law
  • Hot off the Press

    • You have access
      MxB/Mx2: the latest piece in HIV's interferon puzzle
      1. Oliver T Fackler1 and
      2. Oliver T Keppler2
      1. 1 Department of Infectious Diseases, University Hospital Heidelberg, Germany
      2. 2 Institute of Medical Virology, University of Frankfurt, Germany

      Three groups have recently shown in Nature and Cell Host & Microbe that MxB/Mx2 is an interferon‐inducible HIV restriction factor, adding to the innate arsenal of the cell against the virus and paving the way for the possible development of new antiviral strategies.

      • Copyright © 2013 European Molecular Biology Organization
      Oliver T Fackler, Oliver T Keppler
      Published online 01.12.2013
      • Microbiology, Virology & Host Pathogen Interaction
    • You have access
      Remodelling without a power stroke
      1. Arnob Dutta1 and
      2. Jerry L Workman1
      1. 1 Stowers Institute for Medical Research, Kansas City, Missouri, USA

      Although chromatin remodellers are thought to exert power strokes to move nucleosomes along DNA, two studies in this issue show that a power stroke is not required for efficient remodelling, indicating that the DNA binding domain primarily tethers remodellers to nucleosomes.

      • Copyright © 2013 European Molecular Biology Organization
      Arnob Dutta, Jerry L Workman
      Published online 01.12.2013
      • Chromatin, Epigenetics, Genomics & Functional Genomics
    • You have access
      Human Primpol1: a novel guardian of stalled replication forks
      1. Jun‐Sub Im1,†,
      2. Kyung Yong Lee1,†,
      3. Laura W Dillon1 and
      4. Anindya Dutta1
      1. 1 Department of Biochemistry and Molecular Genetics, University of Virginia School of Medicine, Charlottesville, Virginia, USA
      1. ↵† These authors contributed equally to this work.

      Huang and colleagues identify a human primase‐polymerase that is required for stalled replication fork restart and the maintenance of genome integrity.

      • Copyright © 2013 European Molecular Biology Organization
      Jun‐Sub Im, Kyung Yong Lee, Laura W Dillon, Anindya Dutta
      Published online 01.12.2013
      • DNA Replication, Repair & Recombination

Science & Society

  • You have access
    From promise to practiceThe role of synthetic biology in green chemistry

    The role of synthetic biology in green chemistry

    1. David R Nielsen1 and
    2. Tae Seok Moon2
    1. 1 School for Engineering of Matter, Transport, and Energy, Arizona State University, Tempe, Arizona, USA
    2. 2 Department of Energy, Environmental & Chemical Engineering, Washington University, St Louis, Missouri, USA

    Synthetic biology has the potential to profoundly change the way we produce many chemicals, as well as to reduce the environmental impact of the chemical industry.

    • Copyright © 2013 European Molecular Biology Organization
    David R Nielsen, Tae Seok Moon
    Published online 01.12.2013
    • S&S: Technology
  • You have access
    Complex diseases require complex therapies
    1. Ravi Iyengar1
    1. 1 Department of Pharmacology and Systems Therapeutics, Systems Biology Centre New York, Icahn School of Medicine, New York, New York, USA

    Understanding disease causes and drug action at the molecular and systems levels could help to identify combinations of drugs that are more effective than individual drugs alone.

    • Copyright © 2013 European Molecular Biology Organization
    Ravi Iyengar
    Published online 01.12.2013
    • S&S: Health & Disease
    • S&S: Technology
  • You have access
    Tapping the crowds for research fundingCrowdfunding, a common practice to support projects in the arts, music or gaming, has also attracted the attention of scientists

    Crowdfunding, a common practice to support projects in the arts, music or gaming, has also attracted the attention of scientists

    1. Katrin Weigmann1
    1. 1 Oldenburg, Germany

    Scientists are exploring crowdfunding as a potential new source of cash for their research.

    • Copyright © 2013 European Molecular Biology Organization
    Katrin Weigmann
    Published online 01.12.2013
    • S&S: Politics, Policy & Law
  • You have access
    EU‐LIFE revives funding debateA group of mid‐level life science research institutes is reopening the debate on how to fund research at the EU level calling for a stronger emphasis on excellence

    A group of mid‐level life science research institutes is reopening the debate on how to fund research at the EU level calling for a stronger emphasis on excellence

    1. Philip Hunter1
    1. 1 London, UK

    EU‐LIFE, which represents 10 European life science research institutes, has reopened the debate about how to fund research at the European level by calling for the budget of the European Research Council to be drastically increased.

    • Copyright © 2013 European Molecular Biology Organization
    Philip Hunter
    Published online 01.12.2013
    • S&S: Politics, Policy & Law

Review

  • You have access
    Building and remodelling Cullin–RING E3 ubiquitin ligases
    1. John R Lydeard1,
    2. Brenda A Schulman2 and
    3. J Wade Harper*,1
    1. 1 Department of Cell Biology, Harvard Medical School, Boston, Massachusetts, 02115, USA
    2. 2 Departments of Structural Biology and Tumour Cell Biology, Howard Hughes Medical Institute, St Jude Children's Research Hospital, Memphis, Tennessee, 38105, USA
    1. ↵*Corresponding author. Tel: (617) 432‐6590; Fax: (617) 432‐6591; E-mail: wade_harper{at}hms.harvard.edu

    Cullin‐RING E3 ubiquitin ligases (CRLs) are multiprotein complexes that ubiquitylate a plethora of signalling proteins, thereby broadly affecting cellular processes. This review is focused on how CRLs are dynamically controlled, with an emphasis on neddylation cycles and substrate receptor exchange.

    • cullin
    • ubiquitin
    • Nedd8
    • COP9 signalosome
    • E3 ligase
    • CAND1
    • Received September 3, 2013.
    • Accepted October 8, 2013.
    • Copyright © 2013 European Molecular Biology Organization
    John R Lydeard, Brenda A Schulman, J Wade Harper
    Published online 01.12.2013
    • Post-translational Modifications, Proteolysis & Proteomics
    • Signal Transduction
  • You have access
    Cellular dynamics in the muscle satellite cell niche
    1. C Florian Bentzinger1,
    2. Yu Xin Wang1,2,
    3. Nicolas A Dumont1 and
    4. Michael A Rudnicki*,1,2
    1. 1 Sprott Center for Stem Cell Research, Ottawa Hospital Research Institute, 501 Smyth Road, Ottawa, Ontario, K1H 8L6, Canada
    2. 2 Faculty of Medicine, Department of Cellular and Molecular Medicine, University of Ottawa, 451 Smyth Road, Ottawa, Ontario, K1H 8M5, Canada
    1. ↵*Corresponding author. Tel: 00 1 (613) 739 6740; Fax: 00 1 (613) 739 6294; E-mail: mrudnicki{at}ohri.ca

    Multiple, functionally diverse cell types have been shown to contribute to skeletal muscle regeneration. This Review discusses the cellular dynamics and the roles of immune, fibrogenic, vessel‐associated and myogenic cells in the response of the satellite cell niche to muscle injury and disease.

    • skeletal muscle satellite cells
    • muscle stem cell niche
    • accessory cell types
    • myogenic cell types
    • muscular dystrophy
    • Received September 5, 2013.
    • Accepted October 21, 2013.
    • Copyright © 2013 European Molecular Biology Organization
    C Florian Bentzinger, Yu Xin Wang, Nicolas A Dumont, Michael A Rudnicki
    Published online 01.12.2013
    • Development & Differentiation
    • Molecular Biology of Disease
  • Open Access
    Three wise centromere functions: see no error, hear no break, speak no delay
    1. Tomoyuki U Tanaka*,1,
    2. Lesley Clayton1 and
    3. Toyoaki Natsume1,2
    1. 1 Centre for Gene Regulation and Expression, College of Life Sciences, University of Dundee, Dow Street, Dundee, DD1 5EH, UK
    2. 2 Present address: Molecular Function Laboratory, Centre for Frontier Research, National Institute of Genetics, Mishima, Shizuoka, Japan
    1. ↵*Corresponding author. Tel: +44‐1382‐385814; Fax: +44‐1382‐386375; E-mail: t.tanaka{at}dundee.ac.uk

    Centromeres are known to promote kinetochore assembly. However, two other roles—facilitating robust sister chromatid cohesion and advancing the replication timing of centromeric regions—have recently emerged. The three are analysed in this Review.

    • centromere
    • kinetochore
    • microtubule attachment
    • sister‐kinetochore bi‐orientation
    • sister‐chromatid cohesion
    • DNA replication timing
    • Received September 5, 2013.
    • Accepted October 18, 2013.
    • Copyright © 2013 European Molecular Biology Organization

    This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.

    Tomoyuki U Tanaka, Lesley Clayton, Toyoaki Natsume
    Published online 01.12.2013
    • Cell Cycle

Scientific Reports

  • Open Access
    PARP1 orchestrates variant histone exchange in signal‐mediated transcriptional activation
    1. Amanda O'Donnell1,
    2. Shen‐Hsi Yang1 and
    3. Andrew D Sharrocks*,1
    1. 1 Faculty of Life Sciences, University of Manchester, Manchester, UK
    1. ↵*Corresponding author. Tel:+44 (0)161 275 5979; Fax:+44 (0)161 275 5082; E-mail: a.d.sharrocks{at}man.ac.uk

    This study reveals an essential role for PARP1 in the exchange of the histone variant H2A.Z by H2A at the ‐1 nucleosome of the FOS promoter, which promotes signal‐induced transcriptional activation.

    • chromatin
    • H2A.Z
    • immediate early genes
    • MAP kinase signalling
    • PARP
    • Received August 2, 2013.
    • Accepted September 16, 2013.
    • Copyright © 2013 European Molecular Biology Organization

    This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.

    Amanda O'Donnell, Shen‐Hsi Yang, Andrew D Sharrocks
    Published online 01.12.2013
    • Chromatin, Epigenetics, Genomics & Functional Genomics
  • You have access
    No need for a power stroke in ISWI‐mediated nucleosome sliding
    1. Johanna Ludwigsen1,
    2. Henrike Klinker1,2 and
    3. Felix Mueller‐Planitz*,1
    1. 1 Adolf‐Butenandt‐Institute, Ludwig‐Maximilians‐Universität, 80336, Munich, Germany
    2. 2 Center for Integrated Protein Science Munich, Ludwig‐Maximilians‐Universität, Munich, Germany
    1. ↵*Corresponding author. Tel:+089 2180 75 431; Fax:+089 2180 75 425; E-mail: felix.mueller-planitz{at}med.uni-muenchen.de

    Nucleosome remodellers are thought to mechanically pull extranucleosomal DNA into the nucleosome. Surprisingly, even when the mechanical step is experimentally prevented, ISWI can still reposition nucleosomes. The authors discuss alternative models to explain the mechanism.

    • ISWI
    • chromatin remodelling
    • nucleosome sliding
    • Received July 23, 2013.
    • Revision received September 4, 2013.
    • Accepted September 16, 2013.
    • Copyright © 2013 European Molecular Biology Organization
    Johanna Ludwigsen, Henrike Klinker, Felix Mueller‐Planitz
    Published online 01.12.2013
    • Chromatin, Epigenetics, Genomics & Functional Genomics
    • Post-translational Modifications, Proteolysis & Proteomics
  • You have access
    Nucleosome sliding by Chd1 does not require rigid coupling between DNA‐binding and ATPase domains
    1. Ilana M Nodelman1 and
    2. Gregory D Bowman*,1
    1. 1 T.C. Jenkins Department of Biophysics, Johns Hopkins University, Baltimore, MD, 21218, USA
    1. ↵*Corresponding author. Tel:+1 410 516 7850; Fax:+1 410 516 4118; E-mail: gdbowman{at}jhu.edu

    Chromatin remodellers are thought to require a rigid connection between ATPase and DNA‐binding domain to reposition nucleosomes. However, the linking segment of Chd1 can accommodate large changes in length and flexibility, showing that current models for remodeller activity must be revised.

    • Chd1
    • chromatin remodeller
    • nucleosome sliding
    • Received July 24, 2013.
    • Revision received September 11, 2013.
    • Accepted September 17, 2013.
    • Copyright © 2013 European Molecular Biology Organization
    Ilana M Nodelman, Gregory D Bowman
    Published online 01.12.2013
    • Chromatin, Epigenetics, Genomics & Functional Genomics
  • You have access
    hPrimpol1/CCDC111 is a human DNA primase‐polymerase required for the maintenance of genome integrity
    1. Li Wan1,†,
    2. Jiangman Lou1,†,
    3. Yisui Xia2,†,
    4. Bei Su1,
    5. Ting Liu1,
    6. Jiamin Cui2,
    7. Yingying Sun1,
    8. Huiqiang Lou*,2 and
    9. Jun Huang*,1
    1. 1 Life Sciences Institute, Zhejiang University, Hangzhou, Zhejiang, 310058, China
    2. 2 State key laboratory of Agro‐Biotechnology, College of Biological Sciences, Agricultural University, Beijing, 100193, China
    1. ↵*Corresponding authors. Tel:+86 10 6273 4504; Fax:+86 10 6273 4504; E-mail: lou{at}cau.edu.cn or Tel:+86 571 8898 1391; Fax:+86 571 8898 1391; E-mail: jhuang{at}zju.edu.cn
    1. ↵† These authors contributed equally to this work.

    This study identifies the first human DNA primase‐polymerase, which is required for stalled replication fork restart and the maintenance of genome integrity.

    • hPrimpol1/CCDC111
    • primase‐polymerase
    • RPA1
    • stalled replication fork
    • Received July 25, 2013.
    • Revision received September 17, 2013.
    • Accepted September 17, 2013.
    • Copyright © 2013 European Molecular Biology Organization
    Li Wan, Jiangman Lou, Yisui Xia, Bei Su, Ting Liu, Jiamin Cui, Yingying Sun, Huiqiang Lou, Jun Huang
    Published online 01.12.2013
  • Open Access
    Tpo1‐mediated spermine and spermidine export controls cell cycle delay and times antioxidant protein expression during the oxidative stress response
    1. Antje Krüger1,2,
    2. Jakob Vowinckel1,
    3. Michael Mülleder1,
    4. Phillip Grote2,
    5. Floriana Capuano1,
    6. Katharina Bluemlein1,† and
    7. Markus Ralser*,1,3
    1. 1 Cambridge Systems Biology Centre and Department of Biochemistry, University of Cambridge, 80 Tennis Court Road, CB2 1GA, Cambridge, UK
    2. 2 Max Planck Institute for Molecular Genetics, 14195, Berlin, Germany
    3. 3 Division of Physiology and Metabolism, MRC National Institute for Medical Research, The Ridgeway, Mill Hill, London, NW7 1AA, UK
    1. ↵*Corresponding author. Tel:+44 (0)1223 761346; Fax:+44 (0)1223 766002; E-mail: mr559{at}cam.ac.uk
    • ↵† Present address: Quotient Bioresearch, CB7 5WW Fordham, Cambridgeshire, UK

    Cellular export of the metabolites spermine and spermidine is induced under oxidative stress to control the timing of antioxidant gene expression and cell cycle delay and to promote cell survival.

    • oxidative stress response
    • polyamines
    • cell cycle arrest
    • metabolite export
    • timing
    • Received August 29, 2013.
    • Revision received September 20, 2013.
    • Accepted September 20, 2013.
    • Copyright © 2013 European Molecular Biology Organization

    This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.

    Antje Krüger, Jakob Vowinckel, Michael Mülleder, Phillip Grote, Floriana Capuano, Katharina Bluemlein, Markus Ralser
    Published online 01.12.2013
    • Metabolism
    • Post-translational Modifications, Proteolysis & Proteomics
  • You have access
    Interaction with both ZNRF3 and LGR4 is required for the signalling activity of R‐spondin
    1. Yang Xie1,†,
    2. Raffaella Zamponi1,
    3. Olga Charlat1,
    4. Melissa Ramones1,
    5. Susanne Swalley1,
    6. Xiaomo Jiang1,
    7. Daniel Rivera1,
    8. William Tschantz1,
    9. Bo Lu1,
    10. Lisa Quinn1,
    11. Chris Dimitri1,
    12. Jefferson Parker1,
    13. Doug Jeffery1,
    14. Sheri K Wilcox2,
    15. Mike Watrobka2,
    16. Peter LeMotte1,
    17. Brian Granda1,
    18. Jeffrey A Porter1,
    19. Vic E Myer1,
    20. Andreas Loew1 and
    21. Feng Cong*,1
    1. 1 Novartis Institutes for Biomedical Research, 250 Massachusetts Avenue, Cambridge, Massachusetts, 02139, USA
    2. 2 SomaLogic, Inc., 2945 Wilderness Place, Boulder Colorado, 80301, USA
    1. ↵*Corresponding author. Tel:+1 617 871 7510; Fax:+1 617 871 7262; E-mail: feng.cong{at}novartis.com
    • ↵† Present address: FORMA Therapeutics, Inc., 500 Arsenal Street, Watertown, Massachusetts 02472, USA.

    This study shows that both ZNRF3‐ and LGR4‐binding motifs of R‐spondin are required for its Wnt‐promoting activity. These results support a dual receptor model of R‐spondin signalling, where LGR4 serves as the engagement receptor while ZNRF3 functions as the effector receptor.

    • Wnt
    • R‐spondin; ZNRF3
    • RNF43
    • LGR4
    • Received June 18, 2013.
    • Revision received October 1, 2013.
    • Accepted October 1, 2013.
    • Copyright © 2013 European Molecular Biology Organization
    Yang Xie, Raffaella Zamponi, Olga Charlat, Melissa Ramones, Susanne Swalley, Xiaomo Jiang, Daniel Rivera, William Tschantz, Bo Lu, Lisa Quinn, Chris Dimitri, Jefferson Parker, Doug Jeffery, Sheri K Wilcox, Mike Watrobka, Peter LeMotte, Brian Granda, Jeffrey A Porter, Vic E Myer, Andreas Loew, Feng Cong
    Published online 01.12.2013
    • Signal Transduction
  • Open Access
    Loss of iron triggers PINK1/Parkin‐independent mitophagy
    1. George F G Allen1,
    2. Rachel Toth1,
    3. John James2 and
    4. Ian G Ganley*,1
    1. 1 MRC‐Protein Phosphorylation and Ubiquitylation Unit
    2. 2 Cell Signalling and Immunology, College of Life Sciences, University of Dundee, Dundee, DD1 5EH, UK
    1. ↵*Corresponding author. Tel:+01382 388905; Fax:+01382 223778; E-mail: i.ganley{at}dundee.ac.uk

    A novel mitophagy assay uncovers a new PINK1/Parkin‐independent mitophagy pathway induced by a decrease in iron levels. This pathway is active in fibroblasts of Parkinson patients with Parkin mutations and could be exploited as a potential therapy.

    • autophagy
    • iron/mitophagy
    • PINK1
    • Parkin
    • Received June 4, 2013.
    • Revision received September 30, 2013.
    • Accepted October 1, 2013.
    • Copyright © 2013 European Molecular Biology Organization

    This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.

    George F G Allen, Rachel Toth, John James, Ian G Ganley
    Published online 01.12.2013
    • Metabolism
    • Molecular Biology of Disease
  • You have access
    Tightly controlled WRKY23 expression mediates Arabidopsis embryo development
    1. Wim Grunewald*,1,2,†,
    2. Ive De Smet*,1,2,3,†,
    3. Bert De Rybel4,
    4. Helene S Robert1,2,
    5. Brigitte van de Cotte1,2,
    6. Viola Willemsen5,
    7. Godelieve Gheysen6,
    8. Dolf Weijers4,
    9. Jiří Friml1,2 and
    10. Tom Beeckman1,2
    1. 1 Department of Plant Systems Biology, VIB, and Bioinformatics, Ghent University, 9052, Ghent, Belgium
    2. 2 Department of Plant Biotechnology and Bioinformatics, Ghent University, 9052, Ghent, Belgium
    3. 3 Plant and Crop Sciences Division, School of Biosciences, University of Nottingham, LE12 5RD, Loughborough, UK
    4. 4 Laboratory of Biochemistry, Wageningen University, 6703 HA, Wageningen, The Netherlands
    5. 5 Plant Developmental Biology Wageningen University, 6700 AP, Wageningen, The Netherlands
    6. 6 Department Molecular Biotechnology, Faculty of Bioscience Engineering, Ghent University, 9000, Ghent, Belgium
    1. ↵*Corresponding authors. Tel:+32 92446611; Fax:+32 92446610; E-mail: wim.grunewald{at}vib.be or Tel:+32 93313890; Fax:+32 93313809; E-mail: ive.desmet{at}psb.vib-ugent.be
    1. ↵† These authors contributed equally to this work.

    This study presents evidence that the tightly controlled expression of the transcription factor WRKY23 regulates both auxin‐dependent and auxin‐independent signalling pathways leading to root stem cell niche specification in Arabidopsis.

    • Arabidopsis
    • embryogenesis
    • WRKY
    • Received March 21, 2013.
    • Revision received October 4, 2013.
    • Accepted October 4, 2013.
    • Copyright © 2013 European Molecular Biology Organization
    Wim Grunewald, Ive De Smet, Bert De Rybel, Helene S Robert, Brigitte van de Cotte, Viola Willemsen, Godelieve Gheysen, Dolf Weijers, Jiří Friml, Tom Beeckman
    Published online 01.12.2013
    • Development & Differentiation
    • Plant Biology
    • Signal Transduction
  • You have access
    Piezo1‐dependent stretch‐activated channels are inhibited by Polycystin‐2 in renal tubular epithelial cells
    1. Rémi Peyronnet1,†,
    2. Joana R Martins1,†,
    3. Fabrice Duprat1,
    4. Sophie Demolombe1,
    5. Malika Arhatte1,
    6. Martine Jodar1,
    7. Michel Tauc2,
    8. Christophe Duranton2,
    9. Marc Paulais3,
    10. Jacques Teulon3,
    11. Eric Honoré*,1 and
    12. Amanda Patel1
    1. 1 Institut de Pharmacologie Moléculaire et Cellulaire, LabEx ICST, UMR 7275 CNRS, Université de Nice Sophia Antipolis, Valbonne, France
    2. 2 CNRS‐FRE 472, Laboratoire de Physiomédecine Moléculaire, Université de Nice Sophia Antipolis, Nice, France
    3. 3 UPMC Université Paris 06, UMR 872 CNRS, Laboratoire de Génomique, Physiologie et Physiopathologie Rénales, Paris, France
    1. ↵*Corresponding author. Tel:+33 493 957745; Fax:+33 493 957704; E-mail: honore{at}ipmc.cnrs.fr
    1. ↵† These authors contributed equally to this work.

    This study provides evidence that the activity of renal non‐selective stretch‐activated ion channels (SACs) depends on Piezo1 but is negatively regulated by Polycystin‐2 (PC2). PC2 co‐immunoprecipitates with Piezo1 and deletion of its N‐terminal domain prevents both this interaction and inhibition of SAC activity.

    • Fam38A
    • kidney
    • Piezo1
    • PKD
    • mechanotransduction
    • TRP channels
    • Received May 6, 2013.
    • Revision received October 7, 2013.
    • Accepted October 7, 2013.
    • Copyright © 2013 European Molecular Biology Organization
    Rémi Peyronnet, Joana R Martins, Fabrice Duprat, Sophie Demolombe, Malika Arhatte, Martine Jodar, Michel Tauc, Christophe Duranton, Marc Paulais, Jacques Teulon, Eric Honoré, Amanda Patel
    Published online 01.12.2013
    • Signal Transduction
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In this Issue
Volume 14, Number 12
01 December 2013
EMBO reports: 14 (12)
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