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CATP is a critical component of the Neurospora circadian clock by regulating the nucleosome occupancy rhythm at the frequency locus

Joonseok Cha, Mian Zhou, Yi Liu

Author Affiliations

  1. Joonseok Cha1,
  2. Mian Zhou1 and
  3. Yi Liu*,1
  1. 1 Department of Physiology, The University of Texas Southwestern Medical Center, Dallas, Texas, 75390, USA
  1. *Corresponding author. Tel:+1 214 645 6033; Fax:+1 214 645 6049; E-mail: yi.liu{at}
View Abstract


Rhythmic frq transcription is essential for the function of the Neurospora circadian clock. Here we show that there is a circadian histone occupancy rhythm at the frq promoter that is regulated by FREQUENCY (FRQ). Using a combination of forward genetics and genome sequencing, we identify Clock ATPase (CATP) as an essential clock component. Our results demonstrate that CATP associates with the frq locus and other WCC target genes and promotes histone removal at these loci to allow circadian gene transcription. These results indicate that the rhythmic control of histone occupancy at clock genes is critical for circadian clock function.

There is a Hot off the Press (October 2013) associated with this Scientific Report.

  • Received June 19, 2013.
  • Revision received July 24, 2013.
  • Accepted July 31, 2013.
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