Ligand recognition by A‐class Eph receptors: crystal structures of the EphA2 ligand‐binding domain and the EphA2/ephrin‐A1 complex

Juha P Himanen, Yehuda Goldgur, Hui Miao, Eugene Myshkin, Hong Guo, Matthias Buck, My Nguyen, Kanagalaghatta R Rajashankar, Bingcheng Wang, Dimitar B Nikolov

Author Affiliations

  1. Juha P Himanen1,
  2. Yehuda Goldgur1,
  3. Hui Miao2,
  4. Eugene Myshkin2,
  5. Hong Guo2,
  6. Matthias Buck3,
  7. My Nguyen1,
  8. Kanagalaghatta R Rajashankar4,
  9. Bingcheng Wang*,2 and
  10. Dimitar B Nikolov*,1
  1. 1 Structural Biology Program, Memorial Sloan–Kettering Cancer Center, 1275 York Avenue, New York, New York, 10021, USA
  2. 2 Department of Medicine, Rammelkamp Center for Research, MetroHealth Campus, and Department of Pharmacology and Comprehensive Cancer Center, 2500 MetroHealth Drive, Cleveland, Ohio, 44109, USA
  3. 3 Department of Physiology and Biophysics, School of Medicine, Case Western Reserve University, 10900 Euclid Avenue, Cleveland, Ohio, 44106, USA
  4. 4 NE‐CAT, APS, Argonne National Laboratory, 9700 S. Cass Avenue, Argonne, Illinois, 60439, USA
  1. *Corresponding authors. Tel: +1 216 778 4256; Fax: +1 216 778 4321; E-mail: bxw14{at} or Tel: +1 212 639 6784; Fax: +1 212 717 3135; E-mail: nikolovd{at}
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