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S&S: Health & Disease

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    Next generation partnerships in translational science and medicinePartnerships between academics, big pharma, biotech firms, philanthropists and patients look set to change the way science advances
    Next generation partnerships in translational science and medicine

    Partnerships between academics, big pharma, biotech firms, philanthropists and patients look set to change the way science advances

    1. Hans‐Gustaf Ljunggren (hans-gustaf.ljunggren{at}ki.se)1 and
    2. Kenneth R Chien (kenneth.chien{at}ki.se)1
    1. 1Karolinska Institutet, Stockholm, Sweden

    Academic biomedical research and clinical studies are increasingly funded by and conducted in collaboration with partners from industry, patient organizations, charities, and philanthropists. These new partnerships are a much‐needed source of funds and expertise to advance translational medical research.

    • © 2015 The Authors
    Hans‐Gustaf Ljunggren, Kenneth R Chien
    Published online 01.10.2015
    • S&S: Careers & Training
    • S&S: Health & Disease
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    Phoning in sick—telehealth in the iPhone ageAs mobile devices become ubiquitous, can health care finally be delivered effectively over the Internet?
    Phoning in sick—telehealth in the iPhone age

    As mobile devices become ubiquitous, can health care finally be delivered effectively over the Internet?

    1. Philip Hunter, Freelance journalist (ph{at}philiphunter.com)1
    1. 1 London, UK

    A convergence of communications and IT technology, rising costs for health care and the growing market for personal fitness and well‐being are driving projects to implement telehealth care on increasingly large scales.

    • © 2015 The Author
    Philip Hunter
    Published online 01.10.2015
    • S&S: Health & Disease
    • S&S: Technology
  • Open Access
    Mitochondrial replacement to prevent the transmission of mitochondrial DNA disease
    Mitochondrial replacement to prevent the transmission of mitochondrial DNA disease
    1. Mary Herbert (mary.herbert{at}ncl.ac.uk) 1 and
    2. Doug Turnbull (doug.turnbull{at}ncl.ac.uk) 2
    1. 1Wellcome Trust Centre for Mitochondrial Research, Institute of Genetic Medicine, Newcastle University, Newcastle upon Tyne, UK
    2. 2Wellcome Trust Centre for Mitochondrial Research, Institute of Neuroscience, Newcastle University, Newcastle upon Tyne, UK

    New regulations passed in the UK pave the way for treatments using mitochondrial replacement to allow families with mitochondrial DNA disorders to have healthy children, and improve the lives of patients living with such diseases.

    • © 2015 The Authors. Published under the terms of the CC BY 4.0 license

    This is an open access article under the terms of the Creative Commons Attribution 4.0 License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.

    Mary Herbert, Doug Turnbull
    Published online 01.05.2015
    • Genetics, Gene Therapy & Genetic Disease
    • Molecular Biology of Disease
    • S&S: Health & Disease
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    Antibiotic discovery goes undergroundThe discovery of teixobactin could revitalise the search for new antibiotics based on the novel method the researchers used to identify the compound
    Antibiotic discovery goes underground

    The discovery of teixobactin could revitalise the search for new antibiotics based on the novel method the researchers used to identify the compound

    1. Philip Hunter, Freelance journalist (ph{at}philiphunter.com) 1
    1. 1 London, UK

    Early in 2015, researchers reported the discovery of an entirely new antibiotic. The ingenious method they used to find it could greatly benefit the search for novel drugs to fight multi‐drug resistant pathogens.

    • © 2015 The Author
    Philip Hunter
    Published online 01.05.2015
    • S&S: Health & Disease
    • S&S: Technology
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    Risks inherent to mitochondrial replacement
    Risks inherent to mitochondrial replacement
    1. Edward H Morrow*,1,
    2. Klaus Reinhardt2,
    3. Jonci N Wolff3 and
    4. Damian K Dowling3
    1. 1Evolution, Behaviour and Environment Group, School of Life Sciences, University of Sussex, Brighton, UK
    2. 2Applied Zoology, Department of Biology, Technische Universitaet Dresden, Dresden, Germany
    3. 3School of Biological Sciences, Monash University, Clayton, Vic., Australia
    1. ↵*Corresponding author. Tel: +44 1273 87 2862; E‐mail: ted.morrow{at}sussex.ac.uk

    Questions remain about the long‐term safety of mitochondrial replacement.

    • Received May 30, 2014.
    • Revision received January 15, 2015.
    • Accepted March 2, 2015.
    • © 2015 The Authors
    Edward H Morrow, Klaus Reinhardt, Jonci N Wolff, Damian K Dowling
    Published online 01.05.2015
    • Genetics, Gene Therapy & Genetic Disease
    • Molecular Biology of Disease
    • S&S: Health & Disease
  • You have access
    Attacking the systemNext‐generation auto‐immune therapies target pathways rather than symptoms
    Attacking the system

    Next‐generation auto‐immune therapies target pathways rather than symptoms

    1. Philip Hunter (ph{at}philiphunter.com) 1
    1. 1 London, UK

    The prevalence of auto‐immune diseases is an increasing burden for patients and healthcare systems. A new generation of drugs that modify specific signaling pathways of the immune system promises to substantially alleviate the impact of many of these diseases.

    • © 2015 The Author
    Philip Hunter
    Published online 01.04.2015
    • Immunology
    • S&S: Health & Disease
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    Changing the future, not the past: a translational paradigm shift in treating anxiety
    Changing the future, not the past: a translational paradigm shift in treating anxiety
    1. Jürgen Margraf (juergen.margraf{at}rub.de) 1 and
    2. Armin Zlomuzica1
    1. 1Mental Health Research and Treatment Center, University of Bochum, Bochum, Germany

    Understanding how long‐term memories are enshrined at the molecular level has led to new drug targets for treating anxiety disorders. But drugs do not provide lasting effects and we need to find ways to better couple them with therapy to help patients cope with traumatic experiences.

    • © 2015 The Authors
    Jürgen Margraf, Armin Zlomuzica
    Published online 01.03.2015
    • Chromatin, Epigenetics, Genomics & Functional Genomics
    • Neuroscience
    • S&S: Health & Disease
  • You have access
    Medicinal use of cannabis in EuropeThe fact that more countries legalize the medicinal use of cannabis should not become an argument for unfettered and uncontrolled use
    Medicinal use of cannabis in Europe

    The fact that more countries legalize the medicinal use of cannabis should not become an argument for unfettered and uncontrolled use

    1. Maurizio Bifulco (mbifulco{at}unisa.it) 1 and
    2. Simona Pisanti1
    1. 1University of Salerno, Baronissi, Italy

    The use of cannabis to treat chronic pain from cancer or neurological diseases is now legal in many countries. However, the uncontrolled smoking of cannabis leads to neurological harm and cannabis should be treated like any prescription drug to achieve the best effect for patients and safety for the public.

    • © 2015 The Authors
    Maurizio Bifulco, Simona Pisanti
    Published online 01.02.2015
    • S&S: Health & Disease
    • S&S: Politics, Policy & Law
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    Do we understand the personalized medicine paradigm?Personalized medicine marks the beginning of a new attitude in medicine
    Do we understand the personalized medicine paradigm?

    Personalized medicine marks the beginning of a new attitude in medicine

    1. Krešimir Pavelić1,
    2. Tamara Martinović1 and
    3. Sandra Kraljević Pavelić (sandrakp{at}biotech.uniri.hr) 1
    1. 1Department of Biotechnology, University of Rijeka, Rijeka, Croatia

    Personalized medicine is a new, holistic view of health focused on the individual. Social scientists will need to help handle the inevitable societal, ethical and legal challenges created by these new applications of science and medicine.

    • © 2014 The Authors
    Krešimir Pavelić, Tamara Martinović, Sandra Kraljević Pavelić
    Published online 01.02.2015
    • S&S: Health & Disease
    • S&S: Politics, Policy & Law
  • You have access
    Living too longThe current focus of medical research on increasing the quantity, rather than the quality, of life is damaging our health and harming the economy
    Living too long

    The current focus of medical research on increasing the quantity, rather than the quality, of life is damaging our health and harming the economy

    1. Guy C Brown (gcb3{at}cam.ac.uk) 1
    1. 1Department of Biochemistry, University of Cambridge, Cambridge, UK

    Longer lifespans, often ending with multiple diseases, threaten the viability of social and health systems. Rather than prolonging life further, research and funding should focus on increasing the quality of life in old age.

    • © 2014 The Author
    Guy C Brown
    Published online 01.02.2015
    • Ageing
    • S&S: Economics & Business
    • S&S: Health & Disease

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Subject areas

  • Ageing (25)
  • Cancer (191)
  • Cell Adhesion, Polarity & Cytoskeleton (184)
  • Cell Cycle (208)
  • Autophagy & Cell Death (216)
  • Chemical Biology (10)
  • Chromatin, Epigenetics, Genomics & Functional Genomics (370)
  • Development & Differentiation (261)
  • DNA Replication, Repair & Recombination (216)
  • Ecology (22)
  • Evolution (90)
  • Genetics, Gene Therapy & Genetic Disease (29)
  • Immunology (245)
  • Membrane & Intracellular Transport (423)
  • Metabolism (211)
  • Methods & Resources (74)
  • Microbiology, Virology & Host Pathogen Interaction (279)
  • Molecular Biology of Disease (284)
  • Neuroscience (276)
  • Physiology (28)
  • Plant Biology (93)
  • Post-translational Modifications, Proteolysis & Proteomics (383)
  • Protein Biosynthesis & Quality Control (68)
  • RNA Biology (261)
  • Signal Transduction (402)
  • Stem Cells (112)
  • Structural Biology (208)
  • Synthetic Biology & Biotechnology (30)
  • Systems & Computational Biology (60)
  • Transcription (93)
  • Vascular Biology & Angiogenesis (19)
  • S&S: Ethics (253)
  • S&S: Careers & Training (301)
  • S&S: Economics & Business (106)
  • S&S: Ecosystems & Environment (305)
  • S&S: Technology (489)
  • S&S: Health & Disease (555)
  • S&S: History & Philosophy of Science (286)
  • S&S: Media & Publishing (242)
  • S&S: Politics, Policy & Law (934)

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