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Cell Cycle

  • You have access
    Transfer–messenger RNA controls the translation of cell‐cycle and stress proteins in Streptomyces
    1. Sharief Barends1,†,
    2. Martin Zehl2,‡,
    3. Sylwia Bialek1,
    4. Ellen de Waal1,
    5. Bjørn A Traag1,
    6. Joost Willemse1,
    7. Ole Nørregaard Jensen2,
    8. Erik Vijgenboom1 and
    9. Gilles P van Wezel*,1
    1. 1 Microbial Development, Leiden Institute of Chemistry, Leiden University, Einsteinweg 55, 2333, CC Leiden, The Netherlands
    2. 2 Protein Research Group, Department of Biochemistry and Molecular Biology, University of Southern Denmark, Campusvej 55, DK‐5230, Odense M, Denmark
    1. ↵*Corresponding author. Tel: +31 715274310; Fax: +31 715274340; E‐mail: g.wezel{at}chem.leidenuniv.nl
    • ↵† Present address: Department of Pharmacognosy, University of Vienna, Althanstrasse 14, A‐1090 Vienna, Austria

    • ↵‡ Present address: ProteoNic, Niels Bohrweg 11‐13, 2333 CA Leiden, The Netherlands.

    The van Wezel group shows that the translation of some mRNAs, encoding stress and cell cycle control proteins, is dependant on tmRNA, though transcription is unaffected. Their data unveil a surprisingly dedicated functionality for tmRNA: promoting the translation of the mRNA that it targets at the expense of sacrificing the first nascent protein.

    • development
    • ribosome
    • ssrA
    • stress
    • termination
    • Received June 16, 2006.
    • Revision received October 29, 2009.
    • Accepted November 2, 2009.
    • Copyright © 2009 European Molecular Biology Organization
    Sharief Barends, Martin Zehl, Sylwia Bialek, Ellen de Waal, Bjørn A Traag, Joost Willemse, Ole Nørregaard Jensen, Erik Vijgenboom, Gilles P van Wezel
    Published online 01.02.2010
    • Cell Cycle
    • Microbiology, Virology & Host Pathogen Interaction
    • RNA Biology
  • You have access
    A matter of choice: the establishment of sister chromatid cohesion
    1. Frank Uhlmann1
    1. 1 Chromosome Segregation Laboratory, Cancer Research UK London Research Institute, London, WC2A 3PX, UK

    In this thought‐provoking Concept, Frank Uhlmann puts forward a model for the establishment of sister chromatid cohesion, crucial for chromosome segregation in mitosis. As cohesin is a member of the Smc subunit‐based protein complex family‐known to mediate long‐range DNA interactions‐Uhlmann proposes that cohesion occurs through the selective stabilization of cohesin‐mediated interactions between DNA products that emerge from the replication forks, thereby enlightening a poorly understood process.

    • DNA replication
    • sister chromatid cohesion
    • chromosome segregation
    • cohesin
    • Smc complexes
    • Received July 2, 2009.
    • Accepted August 19, 2009.
    • Copyright © 2009 European Molecular Biology Organization
    Frank Uhlmann
    Published online 01.10.2009
    • Cell Cycle
    • DNA Replication, Repair & Recombination
  • You have access
    Vesicular stomatitis virus inhibits mitotic progression and triggers cell death
    1. Papia Chakraborty1,
    2. Joachim Seemann1,
    3. Ram K Mishra2,
    4. Jen‐Hsuan Wei1,
    5. Lauren Weil1,
    6. Daniel R Nussenzveig3,4,
    7. Joshua Heiber5,
    8. Glen N Barber5,
    9. Mary Dasso2 and
    10. Beatriz M A Fontoura*,1
    1. 1 Department of Cell Biology, University of Texas Southwestern Medical Center, 5323 Harry Hines Boulevard, Dallas, Texas, 75390, USA
    2. 2 Laboratory of Gene Regulation and Development, National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, Maryland, 20892, USA
    3. 3 Department of Pathology, University of Texas Southwestern Medical Center, Dallas, Texas, 75390, USA
    4. 4 Pathology and Laboratory Medicine Service, Veterans Affairs North Texas Health Care System, Dallas, Texas, 75216, USA
    5. 5 Department of Medicine and Sylvester Cancer Center, University of Miami School of Medicine, Miami, Florida, 33136, USA
    1. ↵*Corresponding author. Tel: +1 214 648 9535; Fax: +1 214 648 8694; E-mail: beatriz.fontoura{at}utsouthwestern.edu

    Charkraborty et al. show here that VSV infection interferes with mitotic progression resulting in cell death. As tumor cells have a high mitotic index, VSV‐mediated mitotic cell death likely contributes to the oncolytic activity of VSV.

    • nuclear pore complex
    • nucleoporins
    • mRNA export
    • mitosis
    • spindle assembly
    • Received January 16, 2009.
    • Revision received June 21, 2009.
    • Accepted June 23, 2009.
    • Copyright © 2009 European Molecular Biology Organization
    Papia Chakraborty, Joachim Seemann, Ram K Mishra, Jen‐Hsuan Wei, Lauren Weil, Daniel R Nussenzveig, Joshua Heiber, Glen N Barber, Mary Dasso, Beatriz M A Fontoura
    Published online 01.10.2009
    • Cell Cycle
  • You have access
    ING2 controls the progression of DNA replication forks to maintain genome stability
    1. Delphine Larrieu1,
    2. Damien Ythier1,
    3. Romuald Binet1,
    4. Christian Brambilla1,
    5. Elisabeth Brambilla1,
    6. Sagar Sengupta2 and
    7. Rémy Pedeux*,1,3
    1. 1 Molecular Bases of Lung Cancer Progression, INSERM U823, Institut Albert Bonniot, Université Joseph Fourier, Grenoble, 38706, Cedex, France
    2. 2 National Institute of Immunology, Aruna Asaf Ali Marg, New Delhi, 110067, India
    3. 3 INSERM U917, IFR140, Faculté de Médecine, Université de Rennes 1, 35043, Rennes, Cedex, France
    1. ↵*Corresponding author. Tel: +33 (0) 4 7654 9464; Fax: +33 (0) 4 7654 9413; E-mail: remy.pedeux{at}ujf-grenoble.fr

    Larrieu et al describe a new function of the candidate tumor suppressive protein ING2 (Inhibitor of Growth 2) in the control of DNA replication during normal S‐phase. By regulating this process, ING2 maintains genome stability and could be one mechanism by which ING2 prevents tumor development.

    • DNA replication
    • genome stability
    • ING2
    • PCNA
    • tumour suppressor
    • Received March 6, 2009.
    • Revision received July 1, 2009.
    • Accepted July 2, 2009.
    • Copyright © 2009 European Molecular Biology Organization
    Delphine Larrieu, Damien Ythier, Romuald Binet, Christian Brambilla, Elisabeth Brambilla, Sagar Sengupta, Rémy Pedeux
    Published online 01.10.2009
    • Cell Cycle
    • DNA Replication, Repair & Recombination
  • Open Access
    Nucleocytoplasmic transport of Alp7/TACC organizes spatiotemporal microtubule formation in fission yeast
    1. Masamitsu Sato*,1,2,4,
    2. Naoyuki Okada2,
    3. Yasutaka Kakui2,
    4. Masayuki Yamamoto2,
    5. Minoru Yoshida3,5 and
    6. Takashi Toda*,1
    1. 1 Laboratory of Cell Regulation, Cancer Research UK, London Research Institute, 44 Lincoln's Inn Fields, London, WC2A 3PX, UK
    2. 2 Department of Biophysics and Biochemistry, Graduate School of Science, University of Tokyo, 7‐3‐1 Hongo, Tokyo, 113‐0033, Japan
    3. 3 Chemical Genetics Laboratory, RIKEN Advanced Science Institute, 2‐1 Hirosawa, Wako, Saitama, 351‐0198, Japan
    4. 4 PRESTO, Japan Science and Technology Agency, 4‐1‐8 Honcho Kawaguchi, Saitama, 332‐0012, Japan
    5. 5 CREST, Japan Science and Technology Agency, 4‐1‐8 Honcho Kawaguchi, Saitama, 332‐0012, Japan
    1. ↵*Corresponding authors. Tel: +81 3 5841 4388; Fax: +81 3 5802 2042; E-mail: masasato{at}biochem.s.u-tokyo.ac.jp or Tel: +44 20 7269 3535; Fax: +44 20 7269 3258; E-mail: takashi.toda{at}cancer.org.uk

    Microtubules undergo drastic spatial reorganization to form bipolar spindles upon mitotic entry. Here, Sato et al show that a conserved complex consisting of Alp7/TACC and Alp14/TOG in fission yeast, which is required for microtubule organization during both interphase and mitosis, shuttles between the cytoplasm and the nucleus,

    • cyclin‐dependent kinase
    • microtubule
    • nuclear transport
    • Ran GTPase
    • TACC–TOG
    • Received February 3, 2009.
    • Revision received June 12, 2009.
    • Accepted June 15, 2009.
    • Copyright © 2009 European Molecular Biology Organization

    This is an open‐access article distributed under the terms of the Creative Commons Attribution License, which permits distribution, and reproduction in any medium, provided the original author and source are credited. This license does not permit commercial exploitation without specific permission.

    Masamitsu Sato, Naoyuki Okada, Yasutaka Kakui, Masayuki Yamamoto, Minoru Yoshida, Takashi Toda
    Published online 01.10.2009
    • Cell Cycle
  • Open Access
    Bub1 and Bub3 promote the conversion from monopolar to bipolar chromosome attachment independently of shugoshin
    Hanna Windecker, Maria Langegger, Stephanie Heinrich, Silke Hauf
    Published online 01.09.2009
    • Cell Cycle
  • You have access
    Cdc5L interacts with ATR and is required for the S‐phase cell‐cycle checkpoint
    Nianxiang Zhang, Ramandeep Kaur, Shamima Akhter, Randy J Legerski
    Published online 01.09.2009
    • Cell Cycle
    • DNA Replication, Repair & Recombination
  • You have access
    Distinct roles of ATR and DNA‐PKcs in triggering DNA damage responses in ATM‐deficient cells
    Nozomi Tomimatsu, Bipasha Mukherjee, Sandeep Burma
    Published online 01.06.2009
    • Cell Cycle
    • DNA Replication, Repair & Recombination
  • You have access
    Direct observation of type 1 fimbrial switching
    Aileen M Adiciptaningrum, Ian C Blomfield, Sander J Tans
    Published online 01.05.2009
    • Cell Cycle
    • Microbiology, Virology & Host Pathogen Interaction
  • You have access
    Revisiting the COP9 signalosome as a transcriptional regulator
    Daniel A Chamovitz
    Published online 01.04.2009
    • Cell Cycle
    • Chromatin, Epigenetics, Genomics & Functional Genomics

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Subject areas

  • Ageing (25)
  • Cancer (191)
  • Cell Adhesion, Polarity & Cytoskeleton (184)
  • Cell Cycle (208)
  • Autophagy & Cell Death (216)
  • Chemical Biology (10)
  • Chromatin, Epigenetics, Genomics & Functional Genomics (370)
  • Development & Differentiation (261)
  • DNA Replication, Repair & Recombination (216)
  • Ecology (22)
  • Evolution (90)
  • Genetics, Gene Therapy & Genetic Disease (29)
  • Immunology (244)
  • Membrane & Intracellular Transport (423)
  • Metabolism (211)
  • Methods & Resources (74)
  • Microbiology, Virology & Host Pathogen Interaction (278)
  • Molecular Biology of Disease (284)
  • Neuroscience (276)
  • Physiology (28)
  • Plant Biology (93)
  • Post-translational Modifications, Proteolysis & Proteomics (383)
  • Protein Biosynthesis & Quality Control (68)
  • RNA Biology (261)
  • Signal Transduction (402)
  • Stem Cells (112)
  • Structural Biology (208)
  • Synthetic Biology & Biotechnology (30)
  • Systems & Computational Biology (60)
  • Transcription (93)
  • Vascular Biology & Angiogenesis (18)
  • S&S: Ethics (253)
  • S&S: Careers & Training (301)
  • S&S: Economics & Business (106)
  • S&S: Ecosystems & Environment (305)
  • S&S: Technology (489)
  • S&S: Health & Disease (555)
  • S&S: History & Philosophy of Science (286)
  • S&S: Media & Publishing (242)
  • S&S: Politics, Policy & Law (934)

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