Cell Cycle
- Transfer–messenger RNA controls the translation of cell‐cycle and stress proteins in Streptomyces
- Sharief Barends1,†,
- Martin Zehl2,‡,
- Sylwia Bialek1,
- Ellen de Waal1,
- Bjørn A Traag1,
- Joost Willemse1,
- Ole Nørregaard Jensen2,
- Erik Vijgenboom1 and
- Gilles P van Wezel*,1
- 1 Microbial Development, Leiden Institute of Chemistry, Leiden University, Einsteinweg 55, 2333, CC Leiden, The Netherlands
- 2 Protein Research Group, Department of Biochemistry and Molecular Biology, University of Southern Denmark, Campusvej 55, DK‐5230, Odense M, Denmark
- ↵*Corresponding author. Tel: +31 715274310; Fax: +31 715274340; E‐mail: g.wezel{at}chem.leidenuniv.nl
The van Wezel group shows that the translation of some mRNAs, encoding stress and cell cycle control proteins, is dependant on tmRNA, though transcription is unaffected. Their data unveil a surprisingly dedicated functionality for tmRNA: promoting the translation of the mRNA that it targets at the expense of sacrificing the first nascent protein.
- Received June 16, 2006.
- Revision received October 29, 2009.
- Accepted November 2, 2009.
- Copyright © 2009 European Molecular Biology Organization
- A matter of choice: the establishment of sister chromatid cohesion
- Frank Uhlmann1
In this thought‐provoking Concept, Frank Uhlmann puts forward a model for the establishment of sister chromatid cohesion, crucial for chromosome segregation in mitosis. As cohesin is a member of the Smc subunit‐based protein complex family‐known to mediate long‐range DNA interactions‐Uhlmann proposes that cohesion occurs through the selective stabilization of cohesin‐mediated interactions between DNA products that emerge from the replication forks, thereby enlightening a poorly understood process.
- Received July 2, 2009.
- Accepted August 19, 2009.
- Copyright © 2009 European Molecular Biology Organization
- Vesicular stomatitis virus inhibits mitotic progression and triggers cell death
- Papia Chakraborty1,
- Joachim Seemann1,
- Ram K Mishra2,
- Jen‐Hsuan Wei1,
- Lauren Weil1,
- Daniel R Nussenzveig3,4,
- Joshua Heiber5,
- Glen N Barber5,
- Mary Dasso2 and
- Beatriz M A Fontoura*,1
- 1 Department of Cell Biology, University of Texas Southwestern Medical Center, 5323 Harry Hines Boulevard, Dallas, Texas, 75390, USA
- 2 Laboratory of Gene Regulation and Development, National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, Maryland, 20892, USA
- 3 Department of Pathology, University of Texas Southwestern Medical Center, Dallas, Texas, 75390, USA
- 4 Pathology and Laboratory Medicine Service, Veterans Affairs North Texas Health Care System, Dallas, Texas, 75216, USA
- 5 Department of Medicine and Sylvester Cancer Center, University of Miami School of Medicine, Miami, Florida, 33136, USA
- ↵*Corresponding author. Tel: +1 214 648 9535; Fax: +1 214 648 8694; E-mail: beatriz.fontoura{at}utsouthwestern.edu
Charkraborty et al. show here that VSV infection interferes with mitotic progression resulting in cell death. As tumor cells have a high mitotic index, VSV‐mediated mitotic cell death likely contributes to the oncolytic activity of VSV.
- Received January 16, 2009.
- Revision received June 21, 2009.
- Accepted June 23, 2009.
- Copyright © 2009 European Molecular Biology Organization
- ING2 controls the progression of DNA replication forks to maintain genome stability
- Delphine Larrieu1,
- Damien Ythier1,
- Romuald Binet1,
- Christian Brambilla1,
- Elisabeth Brambilla1,
- Sagar Sengupta2 and
- Rémy Pedeux*,1,3
- 1 Molecular Bases of Lung Cancer Progression, INSERM U823, Institut Albert Bonniot, Université Joseph Fourier, Grenoble, 38706, Cedex, France
- 2 National Institute of Immunology, Aruna Asaf Ali Marg, New Delhi, 110067, India
- 3 INSERM U917, IFR140, Faculté de Médecine, Université de Rennes 1, 35043, Rennes, Cedex, France
- ↵*Corresponding author. Tel: +33 (0) 4 7654 9464; Fax: +33 (0) 4 7654 9413; E-mail: remy.pedeux{at}ujf-grenoble.fr
Larrieu et al describe a new function of the candidate tumor suppressive protein ING2 (Inhibitor of Growth 2) in the control of DNA replication during normal S‐phase. By regulating this process, ING2 maintains genome stability and could be one mechanism by which ING2 prevents tumor development.
- Received March 6, 2009.
- Revision received July 1, 2009.
- Accepted July 2, 2009.
- Copyright © 2009 European Molecular Biology Organization
- Nucleocytoplasmic transport of Alp7/TACC organizes spatiotemporal microtubule formation in fission yeast
- Masamitsu Sato*,1,2,4,
- Naoyuki Okada2,
- Yasutaka Kakui2,
- Masayuki Yamamoto2,
- Minoru Yoshida3,5 and
- Takashi Toda*,1
- 1 Laboratory of Cell Regulation, Cancer Research UK, London Research Institute, 44 Lincoln's Inn Fields, London, WC2A 3PX, UK
- 2 Department of Biophysics and Biochemistry, Graduate School of Science, University of Tokyo, 7‐3‐1 Hongo, Tokyo, 113‐0033, Japan
- 3 Chemical Genetics Laboratory, RIKEN Advanced Science Institute, 2‐1 Hirosawa, Wako, Saitama, 351‐0198, Japan
- 4 PRESTO, Japan Science and Technology Agency, 4‐1‐8 Honcho Kawaguchi, Saitama, 332‐0012, Japan
- 5 CREST, Japan Science and Technology Agency, 4‐1‐8 Honcho Kawaguchi, Saitama, 332‐0012, Japan
- ↵*Corresponding authors. Tel: +81 3 5841 4388; Fax: +81 3 5802 2042; E-mail: masasato{at}biochem.s.u-tokyo.ac.jp or Tel: +44 20 7269 3535; Fax: +44 20 7269 3258; E-mail: takashi.toda{at}cancer.org.uk
Microtubules undergo drastic spatial reorganization to form bipolar spindles upon mitotic entry. Here, Sato et al show that a conserved complex consisting of Alp7/TACC and Alp14/TOG in fission yeast, which is required for microtubule organization during both interphase and mitosis, shuttles between the cytoplasm and the nucleus,
- Received February 3, 2009.
- Revision received June 12, 2009.
- Accepted June 15, 2009.
- Copyright © 2009 European Molecular Biology Organization
This is an open‐access article distributed under the terms of the Creative Commons Attribution License, which permits distribution, and reproduction in any medium, provided the original author and source are credited. This license does not permit commercial exploitation without specific permission.
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