Cell Cycle
- Nucleocytoplasmic transport of Alp7/TACC organizes spatiotemporal microtubule formation in fission yeast
- Masamitsu Sato*,1,2,4,
- Naoyuki Okada2,
- Yasutaka Kakui2,
- Masayuki Yamamoto2,
- Minoru Yoshida3,5 and
- Takashi Toda*,1
- 1 Laboratory of Cell Regulation, Cancer Research UK, London Research Institute, 44 Lincoln's Inn Fields, London, WC2A 3PX, UK
- 2 Department of Biophysics and Biochemistry, Graduate School of Science, University of Tokyo, 7‐3‐1 Hongo, Tokyo, 113‐0033, Japan
- 3 Chemical Genetics Laboratory, RIKEN Advanced Science Institute, 2‐1 Hirosawa, Wako, Saitama, 351‐0198, Japan
- 4 PRESTO, Japan Science and Technology Agency, 4‐1‐8 Honcho Kawaguchi, Saitama, 332‐0012, Japan
- 5 CREST, Japan Science and Technology Agency, 4‐1‐8 Honcho Kawaguchi, Saitama, 332‐0012, Japan
- ↵*Corresponding authors. Tel: +81 3 5841 4388; Fax: +81 3 5802 2042; E-mail: masasato{at}biochem.s.u-tokyo.ac.jp or Tel: +44 20 7269 3535; Fax: +44 20 7269 3258; E-mail: takashi.toda{at}cancer.org.uk
Microtubules undergo drastic spatial reorganization to form bipolar spindles upon mitotic entry. Here, Sato et al show that a conserved complex consisting of Alp7/TACC and Alp14/TOG in fission yeast, which is required for microtubule organization during both interphase and mitosis, shuttles between the cytoplasm and the nucleus,
- Received February 3, 2009.
- Revision received June 12, 2009.
- Accepted June 15, 2009.
- Copyright © 2009 European Molecular Biology Organization
This is an open‐access article distributed under the terms of the Creative Commons Attribution License, which permits distribution, and reproduction in any medium, provided the original author and source are credited. This license does not permit commercial exploitation without specific permission.
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